Induction of chromosome aberrations in vitro by phenolphthalein: mechanistic studies

• Published in: Mutation research Vol. 457; no. 1-2; p. 15
• Main Authors: Armstrong, M J, Gara, J P, Gealy, 3rd, R, Greenwood, S K, Hilliard, C A, Laws, G M, Galloway, S M
• Format: Journal Article
• Language: English
• Published: Netherlands 20.12.2000
• Subjects: Animals; Antioxidants - pharmacology; Cathartics - toxicity; Cell Line; Chelating Agents - pharmacology; CHO Cells; Chromosome Aberrations; Cricetinae; Deferoxamine - pharmacology; Dimethyl Sulfoxide - pharmacology; DNA - biosynthesis; DNA Adducts - metabolism; DNA Damage; Hepatocytes - drug effects; Hepatocytes - metabolism; Humans; Hydrogen Peroxide - toxicity; In Vitro Techniques; Mice; Microsomes, Liver - metabolism; Mutagens - toxicity; Oxidative Stress; Phenanthrolines - pharmacology; Phenolphthalein - toxicity; Rats; Reactive Oxygen Species - metabolism; Thymidine - pharmacology

Phenolphthalein induces tumors in rodents but because it is negative in assays for mutation in Salmonella and in mammalian cells, for DNA adducts and for DNA strand breaks, its primary mechanism does not seem to be DNA damage. Chromosome aberration (Ab) induction by phenolphthalein in vitro is assoc...