Lung Cancer Mutation Profile of EGFR, ALK, and KRAS: Meta-Analysis and Comparison of Never and Ever Smokers

Highlights • Increased odds of EGFR in adenocarcinomas compared to non-small cell lung cancer. • Increased odds of ALK-EML4 in adenocarcinomas compared to other lung cancers. • Increased odds of EGFR and ALK-EML4 in never smokers compared to ever smokers. • EGFR mutations was higher in Asian women c...

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Bibliographic Details
Published inLung cancer (Amsterdam, Netherlands) Vol. 102; pp. 122 - 134
Main Authors Chapman, Aaron M, Sun, Kathie Y, Ruestow, Peter, Cowan, Dallas M, Madl, Amy K
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.12.2016
Subjects
ALK
EGFR
Hematology, Oncology and Palliative Medicine
Humans
KRAS
Lung cancer
Lung Neoplasms - enzymology
Lung Neoplasms - epidemiology
Lung Neoplasms - genetics
Mutation
Never smokers
Prevalence
Proto-Oncogene Proteins p21(ras) - genetics
Pulmonary/Respiratory
Receptor Protein-Tyrosine Kinases - genetics
Receptor, Epidermal Growth Factor - genetics
Smoking - epidemiology
Smoking - genetics
Smoking - metabolism
ALK
mutation
KRAS
Lung Cancer
never smokers
EGFR
Mutation
Never smokers
Lung cancer
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Summary:Highlights • Increased odds of EGFR in adenocarcinomas compared to non-small cell lung cancer. • Increased odds of ALK-EML4 in adenocarcinomas compared to other lung cancers. • Increased odds of EGFR and ALK-EML4 in never smokers compared to ever smokers. • EGFR mutations was higher in Asian women compared to other ethnicities. • Never smokers had a decreased odds of KRAS mutations among ethnicities
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2016.10.010