Prevalence of CYP2C19 variant alleles and pharmacodynamic variability of aspirin and clopidogrel in Native Americans

• Published in: The American heart journal Vol. 167; no. 3; pp. 413 - 418
• Main Authors: Oestreich, Julie H., Best, Lyle G., Dobesh, Paul P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2014; Elsevier Limited
• Subjects: Aged; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Aspirin - pharmacokinetics; Aspirin - therapeutic use; Cardiovascular; Cardiovascular disease; Coronary Artery Disease - drug therapy; Cytochrome P-450 CYP2C19; Drug therapy; Female; Gene Frequency; Humans; Indians, North American - genetics; Male; Middle Aged; Mortality; Native North Americans; Platelet Aggregation Inhibitors - metabolism; Platelet Aggregation Inhibitors - pharmacokinetics; Platelet Aggregation Inhibitors - therapeutic use; Polymorphism, Genetic; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacokinetics; Ticlopidine - therapeutic use

The prevalence of variant alleles of the CYP2C19 gene has been determined for most population groups, but not Native Americans. Furthermore, the overall effectiveness of clopidogrel and aspirin has not been well studied in Native Americans, although this group has high mortality rates for cardiovasc...