Prevalence of CYP2C19 variant alleles and pharmacodynamic variability of aspirin and clopidogrel in Native Americans - Oestreich, Julie H.; Best, Lyle G.; Dobesh, Paul P. (The American heart journal, 2014)
Keywords: Aged; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Aspirin - pharmacokinetics; Aspirin - therapeutic use; Cardiovascular; Cardiovascular disease; Coronary Artery Disease - drug therapy; Cytochrome P-450 CYP2C19; Drug therapy; Female; Gene Frequency; Humans; Indians, North American - genetics; Male; Middle Aged; Mortality; Native North Americans; Platelet Aggregation Inhibitors - metabolism; Platelet Aggregation Inhibitors - pharmacokinetics; Platelet Aggregation Inhibitors - therapeutic use; Polymorphism, Genetic; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacokinetics; Ticlopidine - therapeutic use