Detecting differential usage of exons from RNA-seq data

• Published in: Genome research Vol. 22; no. 10; pp. 2008 - 2017
• Main Authors: Anders, Simon, Reyes, Alejandro, Huber, Wolfgang
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.10.2012
• Subjects: Algorithms; Alternative Splicing; Animals; Cell Line; Computational Biology - methods; Databases, Nucleic Acid; Exons; Genomics - methods; Humans; Method; Models, Genetic; Pan troglodytes - genetics; RNA - chemistry; RNA - genetics

RNA-seq is a powerful tool for the study of alternative splicing and other forms of alternative isoform expression. Understanding the regulation of these processes requires sensitive and specific detection of differential isoform abundance in comparisons between conditions, cell types, or tissues. W...