Examination of the Enterotoxigenic Escherichia coli Population Structure during Human Infection

• Published in: mBio Vol. 6; no. 3; p. e00501
• Main Authors: Sahl, Jason W., Sistrunk, Jeticia R., Fraser, Claire M., Hine, Erin, Baby, Nabilah, Begum, Yasmin, Luo, Qingwei, Sheikh, Alaullah, Qadri, Firdausi, Fleckenstein, James M., Rasko, David A.
• Format: Journal Article
• Language: English
• Published: United States American Society of Microbiology 09.06.2015; American Society for Microbiology
• Subjects: children; clones; Cluster Analysis; death; developing countries; diarrhea; Diarrhea - microbiology; Diarrhea - pathology; DNA, Bacterial - chemistry; DNA, Bacterial - genetics; enterotoxigenic Escherichia coli; Enterotoxigenic Escherichia coli - classification; Enterotoxigenic Escherichia coli - genetics; Enterotoxigenic Escherichia coli - isolation & purification; Escherichia coli Infections - microbiology; Escherichia coli Infections - pathology; Genetic Variation; Genome, Bacterial; Genotype; human diseases; Humans; Molecular Sequence Data; multilocus sequence typing; Observation; pathogens; patients; Phylogeny; population structure; Sequence Analysis, DNA; therapeutics; vaccine development; virulence; Virulence Factors - genetics
• ISSN: 2161-2129; 2150-7511; 2150-7511
• DOI: 10.1128/mBio.00501-15

Enterotoxigenic E. coli (ETEC) can cause severe diarrhea and death in children in developing countries; however, bacterial diversity in natural infection is uncharacterized. In this study, we explored the natural population variation of ETEC from individuals with cholera-like diarrhea. Genomic seque...