Imaging in Central Nervous System Drug Discovery

• Published in: Seminars in nuclear medicine Vol. 47; no. 1; pp. 89 - 98
• Main Authors: Gunn, Roger N., Rabiner, Eugenii A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2017
• Subjects: Biomarkers - metabolism; Central Nervous System Agents - metabolism; Central Nervous System Agents - pharmacokinetics; Central Nervous System Agents - pharmacology; Drug Discovery - methods; Humans; Molecular Targeted Therapy; Positron-Emission Tomography - methods; Radiology; Tissue Distribution

The discovery and development of central nervous system (CNS) drugs is an extremely challenging process requiring large resources, timelines, and associated costs. The high risk of failure leads to high levels of risk. Over the past couple of decades PET imaging has become a central component of the...