Function of carbonic anhydrase IX in glioblastoma multiforme

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 14; no. 11; pp. 1357 - 1366
• Main Authors: Proescholdt, Martin A, Merrill, Marsha J, Stoerr, Eva-Maria, Lohmeier, Annette, Pohl, Fabian, Brawanski, Alexander
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.11.2012
• Subjects: Basic and Translational Investigations; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Blotting, Western; Brain Neoplasms - enzymology; Brain Neoplasms - mortality; Carbonic Anhydrase IV - metabolism; Cell Adhesion - physiology; Cell Movement - physiology; Female; Glioblastoma - enzymology; Glioblastoma - mortality; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Invasiveness; Prognosis; RNA Interference

Carbonic anhydrase (CA) IX is over-expressed in glioblastoma; however, its functions in this context are unknown. Metabolically, glioblastomas are highly glycolytic, leading to a significant lactic acid load. Paradoxically, the intracellular pH is alkaline. We hypothesized that CAIX contributes to t...