A ketogenic diet increases transport and oxidation of ketone bodies in RG2 and 9L gliomas without affecting tumor growth

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 18; no. 8; pp. 1079 - 1087
• Main Authors: De Feyter, Henk M., Behar, Kevin L., Rao, Jyotsna U., Madden-Hennessey, Kirby, Ip, Kevan L., Hyder, Fahmeed, Drewes, Lester R., Geschwind, Jean-François, de Graaf, Robin A., Rothman, Douglas L.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.08.2016
• Subjects: 3-Hydroxybutyric Acid - metabolism; Animals; Basic and Translational Investigations; Brain Neoplasms - drug therapy; Brain Neoplasms - metabolism; Cell Line, Tumor; Diet, Ketogenic; Disease Models, Animal; Glioma - diet therapy; Glioma - metabolism; Ketone Bodies - metabolism; Male; Monocarboxylic Acid Transporters - metabolism; Rats, Inbred F344; Survival Analysis; Symporters - metabolism; Tumor Burden; glioma; metabolism; ketogenic diet; 13C MRS; MCT1

The dependence of tumor cells, particularly those originating in the brain, on glucose is the target of the ketogenic diet, which creates a plasma nutrient profile similar to fasting: increased levels of ketone bodies and reduced plasma glucose concentrations. The use of ketogenic diets has been of...