Pediatric versus adult drug trials for conditions with high pediatric disease burden

• Published in: Pediatrics (Evanston) Vol. 130; no. 2; p. 285
• Main Authors: Bourgeois, Florence T, Murthy, Srinivas, Pinto, Catia, Olson, Karen L, Ioannidis, John P A, Mandl, Kenneth D
• Format: Journal Article
• Language: English
• Published: United States 01.08.2012
• Subjects: Adult; Age Factors; Child; Cost of Illness; Drug Industry - statistics & numerical data; Drugs, Investigational - adverse effects; Drugs, Investigational - therapeutic use; Evidence-Based Medicine - statistics & numerical data; Female; Humans; Male; Quality Indicators, Health Care - standards; Quality Indicators, Health Care - statistics & numerical data; Randomized Controlled Trials as Topic - standards; Randomized Controlled Trials as Topic - statistics & numerical data; Research Support as Topic; Sweden; Treatment Outcome; Sweden

Optimal treatment decisions in children require sufficient evidence on the safety and efficacy of pharmaceuticals in pediatric patients. However, there is concern that not enough trials are conducted in children and that pediatric trials differ from those performed in adults. Our objective was to me...