Comparison of human gut microbiota in control subjects and patients with colorectal carcinoma in adenoma: Terminal restriction fragment length polymorphism and next-generation sequencing analyses

• Published in: Oncology reports Vol. 35; no. 1; pp. 325 - 333
• Main Authors: KASAI, CHIKA, SUGIMOTO, KAZUSHI, MORITANI, ISAO, TANAKA, JUNICHIRO, OYA, YUMI, INOUE, HIDEKAZU, TAMEDA, MASAHIKO, SHIRAKI, KATSUYA, ITO, MASAAKI, TAKEI, YOSHIYUKI, TAKASE, KOJIRO
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.01.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adenoma - microbiology; Adult; Bacteria; Bacteria - classification; Bacteria - genetics; Bacteria - isolation & purification; Body mass index; Cancer therapies; Colon; Colonoscopy; Colorectal cancer; Colorectal Neoplasms - microbiology; Deoxyribonucleic acid; Development and progression; DNA; DNA, Ribosomal - genetics; Feces - microbiology; Female; Gastrointestinal Microbiome; Genetic aspects; Genotype; Healthy Volunteers; High-Throughput Nucleotide Sequencing - methods; Host-bacteria relationships; Humans; Identification and classification; Inflammation; Japan; Laboratories; Male; Metabolites; Methods; microbiota; Microbiota (Symbiotic organisms); Middle Aged; Mutation; next-generation sequencing; Polymorphism, Restriction Fragment Length; Probiotics; Restriction fragment length polymorphism analysis; RNA, Ribosomal, 16S - genetics; Sequence Analysis, DNA - methods; Studies; terminal restriction fragment length polymorphism; Tumors; Japan
• ISSN: 1021-335X; 1791-2431
• DOI: 10.3892/or.2015.4398

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in Japan. The etiology of CRC has been linked to numerous factors including genetic mutation, diet, life style, inflammation, and recently, the gut microbiota. However, CRC-associated gut microbiota is still largely unexamin...