Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function

• Published in: Development (Cambridge) Vol. 131; no. 20; pp. 4931 - 4942
• Main Authors: Faivre-Sarrailh, Catherine, Banerjee, Swati, Li, Jingjun, Hortsch, Michael, Laval, Monique, Bhat, Manzoor A.
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 15.10.2004; Company of Biologists
• Subjects: Animals; Base Sequence; Cell Adhesion Molecules, Neuronal - genetics; Cell Adhesion Molecules, Neuronal - metabolism; Contactins; Drosophila; Drosophila - genetics; Drosophila - metabolism; Drosophila Proteins - metabolism; Embryo, Nonmammalian - metabolism; Embryo, Nonmammalian - ultrastructure; Intercellular Junctions - metabolism; Intercellular Junctions - ultrastructure; Life Sciences; Microscopy, Electron; Molecular Sequence Data; Nerve Fibers, Myelinated - metabolism; Neurons and Cognition; Sequence Analysis, DNA; Sequence Homology

Septate junctions (SJs) in epithelial and neuronal cells play an important role in the formation and maintenance of charge and size selective barriers. They form the basis for the ensheathment of nerve fibers in Drosophila and for the attachment of myelin loops to axonal surface in vertebrates. The...