Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function

Septate junctions (SJs) in epithelial and neuronal cells play an important role in the formation and maintenance of charge and size selective barriers. They form the basis for the ensheathment of nerve fibers in Drosophila and for the attachment of myelin loops to axonal surface in vertebrates. The...

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Published inDevelopment (Cambridge) Vol. 131; no. 20; pp. 4931 - 4942
Main Authors Faivre-Sarrailh, Catherine, Banerjee, Swati, Li, Jingjun, Hortsch, Michael, Laval, Monique, Bhat, Manzoor A.
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Limited 15.10.2004
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Abstract Septate junctions (SJs) in epithelial and neuronal cells play an important role in the formation and maintenance of charge and size selective barriers. They form the basis for the ensheathment of nerve fibers in Drosophila and for the attachment of myelin loops to axonal surface in vertebrates. The cell-adhesion molecules NRX IV/Caspr/Paranodin (NCP1), contactin and Neurofascin-155 (NF-155) are all present at the vertebrate axo-glial SJs. Mutational analyses have shown that vertebrate NCP1 and its Drosophila homolog, Neurexin IV (NRX IV) are required for the formation of SJs. In this study, we report the genetic, molecular and biochemical characterization of the Drosophila homolog of vertebrate contactin, CONT. Ultrastructural and dye-exclusion analyses of Cont mutant embryos show that CONT is required for organization of SJs and paracellular barrier function. We show that CONT, Neuroglian (NRG) ( Drosophila homolog of NF-155) and NRX IV are interdependent for their SJ localization and these proteins form a tripartite complex. Hence, our data provide evidence that the organization of SJs is dependent on the interactions between these highly conserved cell-adhesion molecules.
AbstractList Septate junctions (SJs) in epithelial and neuronal cells play an important role in the formation and maintenance of charge and size selective barriers. They form the basis for the ensheathment of nerve fibers in Drosophila and for the attachment of myelin loops to axonal surface in vertebrates. The cell-adhesion molecules NRX IV/Caspr/Paranodin (NCP1),contactin and Neurofascin-155 (NF-155) are all present at the vertebrate axo-glial SJs. Mutational analyses have shown that vertebrate NCP1 and its Drosophila homolog, Neurexin IV (NRX IV) are required for the formation of SJs. In this study, we report the genetic, molecular and biochemical characterization of the Drosophila homolog of vertebrate contactin, CONT. Ultrastructural and dye-exclusion analyses of Contmutant embryos show that CONT is required for organization of SJs and paracellular barrier function. We show that CONT, Neuroglian (NRG)(Drosophila homolog of NF-155) and NRX IV are interdependent for their SJ localization and these proteins form a tripartite complex. Hence, our data provide evidence that the organization of SJs is dependent on the interactions between these highly conserved cell-adhesion molecules.
Septate junctions (SJs) in epithelial and neuronal cells play an important role in the formation and maintenance of charge and size selective barriers. They form the basis for the ensheathment of nerve fibers in Drosophila and for the attachment of myelin loops to axonal surface in vertebrates. The cell-adhesion molecules NRX IV/Caspr/Paranodin (NCP1), contactin and Neurofascin-155 (NF-155) are all present at the vertebrate axo-glial SJs. Mutational analyses have shown that vertebrate NCP1 and its Drosophila homolog, Neurexin IV (NRX IV) are required for the formation of SJs. In this study, we report the genetic, molecular and biochemical characterization of the Drosophila homolog of vertebrate contactin, CONT. Ultrastructural and dye-exclusion analyses of Cont mutant embryos show that CONT is required for organization of SJs and paracellular barrier function. We show that CONT, Neuroglian (NRG) (Drosophila homolog of NF-155) and NRX IV are interdependent for their SJ localization and these proteins form a tripartite complex. Hence, our data provide evidence that the organization of SJs is dependent on the interactions between these highly conserved cell-adhesion molecules.
Author Manzoor A. Bhat
Michael Hortsch
Catherine Faivre-Sarrailh
Jingjun Li
Swati Banerjee
Monique Laval
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  givenname: Catherine
  surname: Faivre-Sarrailh
  fullname: Faivre-Sarrailh, Catherine
  organization: Neurobiologie des Interactions Cellulaires et Neurophysiopathologie, UMR 6184 CNRS, Institut Jean-Roche, Boulevard Pierre Dramard, 13916 Marseille Cedex 20,France
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  organization: Department of Cell and Molecular Physiology, Neuroscience Center and Curriculum in Neurobiology, University of North Carolina School of Medicine,Chapel Hill, NC 27599-7545, USA
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  givenname: Jingjun
  surname: Li
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  givenname: Michael
  surname: Hortsch
  fullname: Hortsch, Michael
  organization: Department of Cell and Developmental Biology, University of Michigan, Medical School, Ann Arbor, MI 48109-0616, USA
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  surname: Laval
  fullname: Laval, Monique
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  surname: Bhat
  fullname: Bhat, Manzoor A.
  organization: Department of Cell and Molecular Physiology, Neuroscience Center and Curriculum in Neurobiology, University of North Carolina School of Medicine,Chapel Hill, NC 27599-7545, USA
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Snippet Septate junctions (SJs) in epithelial and neuronal cells play an important role in the formation and maintenance of charge and size selective barriers. They...
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StartPage 4931
SubjectTerms Animals
Base Sequence
Cell Adhesion Molecules, Neuronal - genetics
Cell Adhesion Molecules, Neuronal - metabolism
Contactins
Drosophila
Drosophila - genetics
Drosophila - metabolism
Drosophila Proteins - metabolism
Embryo, Nonmammalian - metabolism
Embryo, Nonmammalian - ultrastructure
Intercellular Junctions - metabolism
Intercellular Junctions - ultrastructure
Life Sciences
Microscopy, Electron
Molecular Sequence Data
Nerve Fibers, Myelinated - metabolism
Neurons and Cognition
Sequence Analysis, DNA
Sequence Homology
Title Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function
URI http://dev.biologists.org/content/131/20/4931.abstract
https://www.ncbi.nlm.nih.gov/pubmed/15459097
https://search.proquest.com/docview/18064780
https://search.proquest.com/docview/66928342
https://hal.science/hal-00094410
Volume 131
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