Structural basis of RNA folding and recognition in an AMP-RNA aptamer complex

• Published in: Nature (London) Vol. 382; no. 6587; pp. 183 - 186
• Main Authors: Jiang, Feng, Kumar, R. Ajay, Jones, Roger A, Patel, Dinshaw J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing 11.07.1996; Nature Publishing Group
• Subjects: Adenosine Monophosphate - chemistry; Adenosine Monophosphate - metabolism; Analytical, structural and metabolic biochemistry; ATP; Base Sequence; Binding Sites; Biochemistry; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Interactions. Associations; Intermolecular phenomena; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular biophysics; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic acids; Physics; Ribonucleic acid; RNA; RNA - chemistry; RNA - metabolism; Rna, ribonucleoproteins; RNA; Solution structure; Molecular complex; Binding site; Secondary structure; ATP; Structural analysis

The catalytic properties of RNA and its well known role in gene expression and regulation are the consequence of its unique solution structures. Identification of the structural determinants of ligand recognition by RNA molecules is of fundamental importance for understanding the biological function...