Dysregulated expression of matrix metalloproteinases and their inhibitors may participate in the pathogenesis of pre-eclampsia and fetal growth restriction

• Published in: Early human development Vol. 90; no. 10; pp. 657 - 664
• Main Authors: Zhu, JiaYu, Zhong, Mei, Pang, ZhanJun, Yu, YanHong
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.10.2014
• Subjects: Advanced Basic Science; Blotting, Western; China; Female; Fetal growth restriction; Fetal Growth Retardation - etiology; Fetal Growth Retardation - physiopathology; Gene Expression Regulation, Enzymologic - physiology; Humans; Immunohistochemistry; Matrix metalloproteinase; Matrix Metalloproteinases - metabolism; Neonatal and Perinatal Medicine; Placenta; Placenta - cytology; Placenta - metabolism; Pre-eclampsia; Pre-Eclampsia - etiology; Pre-Eclampsia - physiopathology; Pregnancy; Statistics, Nonparametric; Tissue inhibitor of metalloproteinase; Tissue Inhibitor of Metalloproteinases - metabolism; Trophoblast invasion; Trophoblast-related diseases; Trophoblasts - metabolism; Trophoblasts - physiology; China; Trophoblast invasion; Placenta; Fetal growth restriction; Tissue inhibitor of metalloproteinase; Trophoblast-related diseases; Matrix metalloproteinase; Pre-eclampsia

Trophoblast invasion into the maternal endometrium serves an important function in human pregnancy. Dysregulation of the finely controlled process of trophoblast invasion can result in a wide spectrum of pregnancy abnormalities. We aimed to elucidate the relationship between the expression of matrix...