IL10, A Tale of an Evolutionarily Conserved Cytokine across Vertebrates

• Published in: Critical reviews in immunology Vol. 36; no. 2; p. 99
• Main Authors: Piazzon, M Carla, Lutfalla, George, Forlenza, Maria
• Format: Journal Article
• Language: English
• Published: United States 2016
• Subjects: Animals; Conserved Sequence; Evolution, Molecular; Humans; Interleukin-10 - chemistry; Interleukin-10 - genetics; Interleukin-10 - immunology; Models, Molecular; Phylogeny

IL10 was discovered in 1989, and since then it has been the subject of intense investigation, which has revealed its potent anti-inflammatory and regulatory activities in most immune processes during infection and disease. In 2003, the first non-mammalian IL10 sequence was identified in teleost fish...