The Constitutive Androstane Receptor Is an Anti-obesity Nuclear Receptor That Improves Insulin Sensitivity

• Published in: The Journal of biological chemistry Vol. 284; no. 38; pp. 25984 - 25992
• Main Authors: Gao, Jie, He, Jinhan, Zhai, Yonggong, Wada, Taira, Xie, Wen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.09.2009; American Society for Biochemistry and Molecular Biology
• Subjects: Adipose Tissue - metabolism; Animals; Diabetes Mellitus, Type 2 - chemically induced; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - prevention & control; Diet; Dietary Fats - adverse effects; Disease Models, Animal; Energy Metabolism - drug effects; Energy Metabolism - genetics; Fatty Acids - genetics; Fatty Acids - metabolism; Fatty Liver - chemically induced; Fatty Liver - genetics; Fatty Liver - metabolism; Fatty Liver - prevention & control; Gluconeogenesis - drug effects; Gluconeogenesis - genetics; Humans; Insulin Resistance; Lipids and Lipoproteins: Metabolism, Regulation, and Signaling; Lipoproteins, VLDL - metabolism; Mice; Mice, Knockout; Muscle, Skeletal - metabolism; Obesity - chemically induced; Obesity - genetics; Obesity - metabolism; Obesity - prevention & control; Oxidation-Reduction - drug effects; PPAR alpha - genetics; PPAR alpha - metabolism; Pyridines - pharmacology; Receptors, Cytoplasmic and Nuclear - agonists; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Cytoplasmic and Nuclear - metabolism; Triglycerides - metabolism

Obesity and type 2 diabetes are related metabolic disorders of high prevalence. The constitutive androstane receptor (CAR) was initially characterized as a xenobiotic receptor regulating the responses of mammals to xenotoxicants. In this study, we have uncovered an unexpected role of CAR in preventi...