Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence

• Published in: Genome research Vol. 22; no. 8; pp. 1395 - 1406
• Main Authors: Gordon, Lavinia, Joo, Jihoon E., Powell, Joseph E., Ollikainen, Miina, Novakovic, Boris, Li, Xin, Andronikos, Roberta, Cruickshank, Mark N., Conneely, Karen N., Smith, Alicia K., Alisch, Reid S., Morley, Ruth, Visscher, Peter M., Craig, Jeffrey M., Saffery, Richard
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.08.2012
• Subjects: Cells, Cultured; CpG Islands; DNA Methylation; Epigenesis, Genetic; Epigenomics - methods; Female; Fetal Development - genetics; Fetal Growth Retardation - genetics; Genetic Drift; Genome, Human; Gestational Age; Human Umbilical Vein Endothelial Cells - cytology; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Infant, Low Birth Weight; Infant, Newborn; Inheritance Patterns; Male; Oligonucleotide Array Sequence Analysis; Organ Specificity; Phenotype; Placenta - cytology; Placenta - metabolism; Pregnancy; Regression Analysis; Stochastic Processes; Twins, Dizygotic - genetics; Twins, Monozygotic - genetics

Comparison between groups of monozygotic (MZ) and dizygotic (DZ) twins enables an estimation of the relative contribution of genetic and shared and nonshared environmental factors to phenotypic variability. Using DNA methylation profiling of ∼20,000 CpG sites as a phenotype, we have examined discord...