Effects of Nanpao®, a Kampo Medicine, on Peripheral Blood Flow and Surface Skin Temperature in Aged Female Rats

The effects of long-term treatment with Nanpao, a kampo medicine, on cold constitution were evaluated in aged female rats. Five-month-old rats were administered Nanpao orally at doses of 0, 30, or 100 mg/kg/day. The peripheral blood flow and surface skin temperature in the hind paws were measured us...

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Published inExperimental Animals Vol. 58; no. 1; pp. 67 - 71
Main Authors ICHIHASHI, Masaru, TAKATANI, Hiromi, HASHIMOTO, Yoshikatsu, YANO, Kouji, NISHIDA, Atsuyuki, KITAMURA, Kazuyuki
Format Journal Article
LanguageEnglish
Published Japan Japanese Association for Laboratory Animal Science 2009
Subjects
Age Factors
Animals
Blood Flow Velocity - drug effects
cold constitution
Dose-Response Relationship, Drug
Drugs, Chinese Herbal - pharmacology
Female
Humans
kampo medicine
Medicine, Kampo
Nanpao
Rats
Rats, Sprague-Dawley
Regional Blood Flow - drug effects
Skin - blood supply
Skin Temperature - drug effects
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Summary:The effects of long-term treatment with Nanpao, a kampo medicine, on cold constitution were evaluated in aged female rats. Five-month-old rats were administered Nanpao orally at doses of 0, 30, or 100 mg/kg/day. The peripheral blood flow and surface skin temperature in the hind paws were measured using a laser Doppler blood flow meter and infrared thermography, respectively. In animals treated with Nanpao, the peripheral blood flow increased dose-dependently compared to that in the control group. Moreover, the surface skin temperature after immersion in ice-cold water was higher in the Nanpao-treated groups than in the control group at all measurement times. These results suggest that Nanpao has the potential to improve cold constitution associated with decreased peripheral blood flow in women.
ISSN:1341-1357
1881-7122
DOI:10.1538/expanim.58.67