Gene Therapy in Neovascular Age-related Macular Degeneration: Three-Year Follow-up of a Phase 1 Randomized Dose Escalation Trial - Constable, Ian J.; Lai, Chooi-May; Magno, Aaron L.; French, Martyn A.; Barone, Samuel B.; Schwartz, Steven D.; Blumenkranz, Mark S.; Degli-Esposti, Mariapia A.; Rakoczy, Elizabeth P. (American journal of ophthalmology, 2017)
Keywords: Age; Aged; Aged, 80 and over; Choroidal Neovascularization - complications; Choroidal Neovascularization - therapy; Diabetes; Diabetic retinopathy; Dose-Response Relationship, Drug; Evidence-based medicine; Female; Follow-Up Studies; Gene therapy; Genetic Therapy - methods; Humans; Injections; Interleukin-1 Receptor-Like 1 Protein - administration & dosage; Laboratories; Macular degeneration; Male; Monoclonal antibodies; Ophthalmology; Pharmaceutical industry; Receptors, Interleukin-1; Retina; Time Factors; Tomography, Optical Coherence; Treatment Outcome; Vascular endothelial growth factor; Visual Acuity; Vitrectomy; Wet Macular Degeneration - physiopathology; Wet Macular Degeneration - therapy