Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease
Yokukansan (YKS) is used frequently against behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer's disease (AD). Here, we investigated the efficacy and safety of YKS in patients with AD in a non-blinded, randomized, parallel-group compariso...
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| Published in | Progress in neuro-psychopharmacology & biological psychiatry Vol. 34; no. 3; pp. 532 - 536 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Amsterdam
Elsevier Inc
16.04.2010
Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0278-5846 1878-4216 1878-4216 |
| DOI | 10.1016/j.pnpbp.2010.02.013 |
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| Abstract | Yokukansan (YKS) is used frequently against behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer's disease (AD). Here, we investigated the efficacy and safety of YKS in patients with AD in a non-blinded, randomized, parallel-group comparison study. Patients who had at least one symptom score of four or more on the Neuropsychiatric Inventory (NPI) subscales were enrolled in the study. The subjects were randomly assigned to the YKS-treated group (YKS/donepezil combination therapy group) and the non-YKS-treated group (donepezil monotherapy group). TSUMURA Yokukansan (TJ-54, 7.5
g, t.i.d.) was administered in a four-week study treatment period. The subjects were evaluated twice at the start (Week 0) and completion (Week 4) of the study treatment in terms of NPI, Mini-Mental Status Examination (MMSE), Disability Assessment for Dementia (DAD), Zarit Burden Interview, and Self-rating Depression Scale (SDS). The efficacy analysis was performed in 29 patients (YKS-treated group) and 32 patients (non-YKS-treated group). The NPI total score improved significantly more in the YKS-treated group than in the non-YKS-treated group. In the NPI subscales of agitation/aggression and irritability/lability, the YKS-treated group showed significantly greater improvement than the non-YKS-treated group, but no statistically significant improvement was seen with YKS in the other subscales. There were no significant differences between the YKS-treated group and the non-YKS-treated group in MMSE, DAD, Zarit Burden Interview and SDS. No adverse reactions were noted in either group. The results of this study showed that YKS is safe and effective in the treatment of BPSD in AD patients. |
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| AbstractList | Yokukansan (YKS) is used frequently against behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer's disease (AD). Here, we investigated the efficacy and safety of YKS in patients with AD in a non-blinded, randomized, parallel-group comparison study. Patients who had at least one symptom score of four or more on the Neuropsychiatric Inventory (NPI) subscales were enrolled in the study. The subjects were randomly assigned to the YKS-treated group (YKS/donepezil combination therapy group) and the non-YKS-treated group (donepezil monotherapy group). TSUMURA Yokukansan (TJ-54, 7.5g, t.i.d.) was administered in a four-week study treatment period. The subjects were evaluated twice at the start (Week 0) and completion (Week 4) of the study treatment in terms of NPI, Mini-Mental Status Examination (MMSE), Disability Assessment for Dementia (DAD), Zarit Burden Interview, and Self-rating Depression Scale (SDS). The efficacy analysis was performed in 29 patients (YKS-treated group) and 32 patients (non-YKS-treated group). The NPI total score improved significantly more in the YKS-treated group than in the non-YKS-treated group. In the NPI subscales of agitation/aggression and irritability/lability, the YKS-treated group showed significantly greater improvement than the non-YKS-treated group, but no statistically significant improvement was seen with YKS in the other subscales. There were no significant differences between the YKS-treated group and the non-YKS-treated group in MMSE, DAD, Zarit Burden Interview and SDS. No adverse reactions were noted in either group. The results of this study showed that YKS is safe and effective in the treatment of BPSD in AD patients. Yokukansan (YKS) is used frequently against behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer's disease (AD). Here, we investigated the efficacy and safety of YKS in patients with AD in a non-blinded, randomized, parallel-group comparison study. Patients who had at least one symptom score of four or more on the Neuropsychiatric Inventory (NPI) subscales were enrolled in the study. The subjects were randomly assigned to the YKS-treated group (YKS/donepezil combination therapy group) and the non-YKS-treated group (donepezil monotherapy group). TSUMURA Yokukansan (TJ-54, 7.5 g, t.i.d.) was administered in a four-week study treatment period. The subjects were evaluated twice at the start (Week 0) and completion (Week 4) of the study treatment in terms of NPI, Mini-Mental Status Examination (MMSE), Disability Assessment for Dementia (DAD), Zarit Burden Interview, and Self-rating Depression Scale (SDS). The efficacy analysis was performed in 29 patients (YKS-treated group) and 32 patients (non-YKS-treated group). The NPI total score improved significantly more in the YKS-treated group than in the non-YKS-treated group. In the NPI subscales of agitation/aggression and irritability/lability, the YKS-treated group showed significantly greater improvement than the non-YKS-treated group, but no statistically significant improvement was seen with YKS in the other subscales. There were no significant differences between the YKS-treated group and the non-YKS-treated group in MMSE, DAD, Zarit Burden Interview and SDS. No adverse reactions were noted in either group. The results of this study showed that YKS is safe and effective in the treatment of BPSD in AD patients. Yokukansan (YKS) is used frequently against behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer's disease (AD). Here, we investigated the efficacy and safety of YKS in patients with AD in a non-blinded, randomized, parallel-group comparison study. Patients who had at least one symptom score of four or more on the Neuropsychiatric Inventory (NPI) subscales were enrolled in the study. The subjects were randomly assigned to the YKS-treated group (YKS/donepezil combination therapy group) and the non-YKS-treated group (donepezil monotherapy group). TSUMURA Yokukansan (TJ-54, 7.5 g, t.i.d.) was administered in a four-week study treatment period. The subjects were evaluated twice at the start (Week 0) and completion (Week 4) of the study treatment in terms of NPI, Mini-Mental Status Examination (MMSE), Disability Assessment for Dementia (DAD), Zarit Burden Interview, and Self-rating Depression Scale (SDS). The efficacy analysis was performed in 29 patients (YKS-treated group) and 32 patients (non-YKS-treated group). The NPI total score improved significantly more in the YKS-treated group than in the non-YKS-treated group. In the NPI subscales of agitation/aggression and irritability/lability, the YKS-treated group showed significantly greater improvement than the non-YKS-treated group, but no statistically significant improvement was seen with YKS in the other subscales. There were no significant differences between the YKS-treated group and the non-YKS-treated group in MMSE, DAD, Zarit Burden Interview and SDS. No adverse reactions were noted in either group. The results of this study showed that YKS is safe and effective in the treatment of BPSD in AD patients. Yokukansan (YKS) is used frequently against behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer's disease (AD). Here, we investigated the efficacy and safety of YKS in patients with AD in a non-blinded, randomized, parallel-group comparison study. Patients who had at least one symptom score of four or more on the Neuropsychiatric Inventory (NPI) subscales were enrolled in the study. The subjects were randomly assigned to the YKS-treated group (YKS/donepezil combination therapy group) and the non-YKS-treated group (donepezil monotherapy group). TSUMURA Yokukansan (TJ-54, 7.5g, t.i.d.) was administered in a four-week study treatment period. The subjects were evaluated twice at the start (Week 0) and completion (Week 4) of the study treatment in terms of NPI, Mini-Mental Status Examination (MMSE), Disability Assessment for Dementia (DAD), Zarit Burden Interview, and Self-rating Depression Scale (SDS). The efficacy analysis was performed in 29 patients (YKS-treated group) and 32 patients (non-YKS-treated group). The NPI total score improved significantly more in the YKS-treated group than in the non-YKS-treated group. In the NPI subscales of agitation/aggression and irritability/lability, the YKS-treated group showed significantly greater improvement than the non-YKS-treated group, but no statistically significant improvement was seen with YKS in the other subscales. There were no significant differences between the YKS-treated group and the non-YKS-treated group in MMSE, DAD, Zarit Burden Interview and SDS. No adverse reactions were noted in either group. The results of this study showed that YKS is safe and effective in the treatment of BPSD in AD patients.Yokukansan (YKS) is used frequently against behavioral and psychological symptoms of dementia (BPSD) together with donepezil in patients with Alzheimer's disease (AD). Here, we investigated the efficacy and safety of YKS in patients with AD in a non-blinded, randomized, parallel-group comparison study. Patients who had at least one symptom score of four or more on the Neuropsychiatric Inventory (NPI) subscales were enrolled in the study. The subjects were randomly assigned to the YKS-treated group (YKS/donepezil combination therapy group) and the non-YKS-treated group (donepezil monotherapy group). TSUMURA Yokukansan (TJ-54, 7.5g, t.i.d.) was administered in a four-week study treatment period. The subjects were evaluated twice at the start (Week 0) and completion (Week 4) of the study treatment in terms of NPI, Mini-Mental Status Examination (MMSE), Disability Assessment for Dementia (DAD), Zarit Burden Interview, and Self-rating Depression Scale (SDS). The efficacy analysis was performed in 29 patients (YKS-treated group) and 32 patients (non-YKS-treated group). The NPI total score improved significantly more in the YKS-treated group than in the non-YKS-treated group. In the NPI subscales of agitation/aggression and irritability/lability, the YKS-treated group showed significantly greater improvement than the non-YKS-treated group, but no statistically significant improvement was seen with YKS in the other subscales. There were no significant differences between the YKS-treated group and the non-YKS-treated group in MMSE, DAD, Zarit Burden Interview and SDS. No adverse reactions were noted in either group. The results of this study showed that YKS is safe and effective in the treatment of BPSD in AD patients. |
| Author | Mitsuyama, Yoshio Kiue, Kouichirou Kawano, Jiro Tomita, Seiichiro Hayashi, Yoshihito Ninomiya, Yoshimasa Hosomi, Jun Yoshida, Kensei Tsuruta, Kazuhito Takeuchi, Kouzou Inoue, Teruhiko Okahara, Kazunori Ishida, Yasushi Yoshimuta, Hirofumi Fujimoto, Masumi Noda, Shouji |
| Author_xml | – sequence: 1 givenname: Kazunori surname: Okahara fullname: Okahara, Kazunori email: k-okahara@keimei.or.jp organization: Keimei Memorial Hospital, 762 Iwachino, Kunitomi-cho, Higashimorokata, Miyazaki 880-1111, Japan – sequence: 2 givenname: Yasushi surname: Ishida fullname: Ishida, Yasushi organization: Division of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake-cho, Miyazaki 889-1692, Japan – sequence: 3 givenname: Yoshihito surname: Hayashi fullname: Hayashi, Yoshihito organization: Division of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake-cho, Miyazaki 889-1692, Japan – sequence: 4 givenname: Teruhiko surname: Inoue fullname: Inoue, Teruhiko organization: Psychogeriatric Center, Daigo Hospital, 1270 Nagata, Mimata-cho, Kitamorokata, Miyazaki 889-1911, Japan – sequence: 5 givenname: Kazuhito surname: Tsuruta fullname: Tsuruta, Kazuhito organization: Koga General Hospital, 1749-1 Sudaki, ikeuchi-cho, Miyazaki 880-0041, Japan – sequence: 6 givenname: Kouzou surname: Takeuchi fullname: Takeuchi, Kouzou organization: Fujimoto Hospital, 17-4 Hayasuzu-cho, Miyakonojo, Miyazaki 885-0055, Japan – sequence: 7 givenname: Hirofumi surname: Yoshimuta fullname: Yoshimuta, Hirofumi organization: Fujimoto Hospital, 17-4 Hayasuzu-cho, Miyakonojo, Miyazaki 885-0055, Japan – sequence: 8 givenname: Kouichirou surname: Kiue fullname: Kiue, Kouichirou organization: Fujimoto Hospital, 17-4 Hayasuzu-cho, Miyakonojo, Miyazaki 885-0055, Japan – sequence: 9 givenname: Yoshimasa surname: Ninomiya fullname: Ninomiya, Yoshimasa organization: Kyowa Hospital, 1194-3 Zaikohji, Hyuga, Miyazaki 883-0021, Japan – sequence: 10 givenname: Jiro surname: Kawano fullname: Kawano, Jiro organization: Kyowa Hospital, 1194-3 Zaikohji, Hyuga, Miyazaki 883-0021, Japan – sequence: 11 givenname: Kensei surname: Yoshida fullname: Yoshida, Kensei organization: Yoshida Hospital, 4-8850 Matsubara-machi, Nobeoka, Miyazaki 889-0511, Japan – sequence: 12 givenname: Shouji surname: Noda fullname: Noda, Shouji organization: Noda Clinic, Wing2-1F, 52 Hagi-machi, Nobeoka, Miyazaki 882-0052, Japan – sequence: 13 givenname: Seiichiro surname: Tomita fullname: Tomita, Seiichiro organization: Hearty Clinic, 2296-6 Yunokida-machi, Nobeoka, Miyazaki 882-0026, Japan – sequence: 14 givenname: Masumi surname: Fujimoto fullname: Fujimoto, Masumi organization: Kennan Hospital, 3728 Nishikata, Kusima, Miyazaki 888-0001, Japan – sequence: 15 givenname: Jun surname: Hosomi fullname: Hosomi, Jun organization: Heartopia Hosomi Clinic, 1-5-3 Tachibanadoori-nishi, Miyazaki 880-0001, Japan – sequence: 16 givenname: Yoshio surname: Mitsuyama fullname: Mitsuyama, Yoshio organization: Psychogeriatric Center, Daigo Hospital, 1270 Nagata, Mimata-cho, Kitamorokata, Miyazaki 889-1911, Japan |
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| Cites_doi | 10.1211/jpp.61.09.0016 10.1093/geront/20.6.649 10.1056/NEJMoa052827 10.1017/S146114570800970X 10.1176/appi.neuropsych.13.1.5 10.1001/archpsyc.1965.01720310065008 10.1111/j.1479-8301.2008.00250.x 10.1016/j.pnpbp.2008.05.010 10.4088/JCP.v66n1219a 10.1111/j.1447-0594.2005.00274.x 10.1212/WNL.44.12.2308 10.7326/0003-4819-146-11-200706050-00006 10.1016/j.neuroscience.2009.02.004 10.1503/cmaj.061250 10.1016/0022-3956(75)90026-6 10.1017/S104161020200858X 10.1016/j.neuint.2008.07.009 10.4088/JCP.v66n0214 10.5014/ajot.53.5.471 10.1097/00002826-200211000-00007 10.1016/j.pnpbp.2008.12.008 |
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| Keywords | BPSD YKS AD SDS Yokukansan DAD NPI ADL Traditional Japanese medicine (kampo medicine) Behavioral and psychological symptoms of dementia (BPSD) MMSE VaD DLB FAST Alzheimer's disease Nervous system diseases Alzheimer disease Japanese Cerebral disorder Behavioral disorder Treatment Folk medicine Central nervous system disease Mental disorder Degenerative disease Behavioural and psychological symptoms of dementia |
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| References | Lanctot, Hermann, Mazzota (bib11) 2001; 13 Takeda, Tamano, Itoh, Oku (bib18) 2008; 53 Kawakami, Kanno, Ueki, Terawaki, Tabuchi, Ikarashi (bib10) 2009; 159 Reisberg (bib16) 1988; 24 Terawaki, Sekiguchi, Yamaguchi, Imamura, Kanno, Ikarashi (bib21) 2008; 47 Iwasaki, Satoh-Nakagawa, Maruyama, Monma, Nemoto, Tomita (bib8) 2005; 66 Liao JF, Huang, Wang HH, Chen (bib12) 1995; B 19 Monji, Takita, Samejima, Takaihi, Hashimoto, Matsunaga (bib14) 2009; 33 Folstein, Folstein, McHugh (bib3) 1975; 12 Paleacu, Mazeh, Mirecki, Even, Barak (bib15) 2002; Vol.25 Schneeweiss, Setoguchi, Brookhart, Dormuth, Wang (bib17) 2007; 176 Wang, Schneeweiss, Avorn, Fischer, Mogun, Solomon (bib22) 2005; 353 Gélinas, Gauthier, McIntyre, Gauthier (bib5) 1999; 53 Tanji, Ootsuki, Matsui, Maruyama, Nemoto, Tomita (bib20) 2005; 5 Zung (bib24) 1965; 12 Kanno, Sekiguchi, Yamaguchi, Terawaki, Yuzurihara, Kase (bib9) 2009; 61 Mizukami, Asada, Kinoshita, Tanaka, Sonohara, Nakai (bib13) 2009; 12 Egashira, Iwasaki, Ishibashi, Hayakawa, Okuno, Abe (bib2) 2008; 32 Tanaka, Kazui, Morihara, Sadik, Kudo, Takeda (bib19) 2008; 8 Gauthier, Feldman, Hecker, Vellas, Ames, Subbiah (bib4) 2002; 14 Cummings, Mega, Gray, Rosenberg-Thompson, Carusi, Gornbein (bib1) 1994; 44 Gill, Bronskill, Normand, Anderson, Sykora, Lam (bib6) 2007; 146 Iwasaki, Maruyama, Tomita, Furukawa, Nemoto, Fujiwara (bib7) 2005; 66 Zarit, Reever, Bach-Peterson (bib23) 1980; 20 Liao JF (10.1016/j.pnpbp.2010.02.013_bib12) 1995; B 19 Tanji (10.1016/j.pnpbp.2010.02.013_bib20) 2005; 5 Zarit (10.1016/j.pnpbp.2010.02.013_bib23) 1980; 20 Gauthier (10.1016/j.pnpbp.2010.02.013_bib4) 2002; 14 Zung (10.1016/j.pnpbp.2010.02.013_bib24) 1965; 12 Wang (10.1016/j.pnpbp.2010.02.013_bib22) 2005; 353 Mizukami (10.1016/j.pnpbp.2010.02.013_bib13) 2009; 12 Lanctot (10.1016/j.pnpbp.2010.02.013_bib11) 2001; 13 Egashira (10.1016/j.pnpbp.2010.02.013_bib2) 2008; 32 Paleacu (10.1016/j.pnpbp.2010.02.013_bib15) 2002; Vol.25 Kawakami (10.1016/j.pnpbp.2010.02.013_bib10) 2009; 159 Terawaki (10.1016/j.pnpbp.2010.02.013_bib21) 2008; 47 Monji (10.1016/j.pnpbp.2010.02.013_bib14) 2009; 33 Kanno (10.1016/j.pnpbp.2010.02.013_bib9) 2009; 61 Takeda (10.1016/j.pnpbp.2010.02.013_bib18) 2008; 53 Iwasaki (10.1016/j.pnpbp.2010.02.013_bib7) 2005; 66 Reisberg (10.1016/j.pnpbp.2010.02.013_bib16) 1988; 24 Gélinas (10.1016/j.pnpbp.2010.02.013_bib5) 1999; 53 Iwasaki (10.1016/j.pnpbp.2010.02.013_bib8) 2005; 66 Schneeweiss (10.1016/j.pnpbp.2010.02.013_bib17) 2007; 176 Folstein (10.1016/j.pnpbp.2010.02.013_bib3) 1975; 12 Tanaka (10.1016/j.pnpbp.2010.02.013_bib19) 2008; 8 Cummings (10.1016/j.pnpbp.2010.02.013_bib1) 1994; 44 Gill (10.1016/j.pnpbp.2010.02.013_bib6) 2007; 146 |
| References_xml | – volume: 12 start-page: 189 year: 1975 end-page: 198 ident: bib3 article-title: “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician publication-title: J Psychiatr Res – volume: 146 start-page: 775 year: 2007 end-page: 786 ident: bib6 article-title: Antipsychotic drug use and mortality in older adults with dementia publication-title: Ann Intern Med – volume: 12 start-page: 191 year: 2009 end-page: 199 ident: bib13 article-title: A randomized crossover study of a traditional Japanese medicine (kampo) “Yokukansan” in the treatment of the behavioral and psychological symptoms of dementia publication-title: Int J Neuropsychopharmacol – volume: 20 start-page: 649 year: 1980 end-page: 655 ident: bib23 article-title: Relatives of the impaired elderly: correlates of feelings of burden publication-title: Gerontologist – volume: 8 start-page: 114 year: 2008 end-page: 123 ident: bib19 article-title: Post-marketing survey of donepezil hydrochloride in Japanese patient with Alzheimer's disease with behavioral and psychological symptoms of dementia (BPSD) publication-title: Psychogeriatrics – volume: B 19 start-page: 151 year: 1995 end-page: 158 ident: bib12 article-title: Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs publication-title: Proceedings of the National Science Council, Republic of China – volume: 5 start-page: 94 year: 2005 end-page: 98 ident: bib20 article-title: Dementia caregivers' burdens and use of public services publication-title: Geriatr Gerontol Internat – volume: 44 start-page: 2308 year: 1994 end-page: 2314 ident: bib1 article-title: The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia publication-title: Neurology – volume: 159 start-page: 1397 year: 2009 end-page: 1407 ident: bib10 article-title: Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells publication-title: Neuroscience – volume: 61 start-page: 1 year: 2009 end-page: 8 ident: bib9 article-title: Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats publication-title: J Pharm Pharmacol – volume: 33 start-page: 308 year: 2009 end-page: 311 ident: bib14 article-title: Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease publication-title: Prog Neuropsychopharmacol Biol Psychiatry – volume: 176 start-page: 627 year: 2007 end-page: 632 ident: bib17 article-title: Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients publication-title: CMAJ – volume: 53 start-page: 230 year: 2008 end-page: 235 ident: bib18 article-title: Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan publication-title: Neurochem Int – volume: 47 start-page: 257 year: 2008 ident: bib21 article-title: Partial agonistic effects for serotonin 1A receptors of yokukansan, a traditional Japanese medicine publication-title: Bull Jpn Soc Neurochem – volume: 14 start-page: 389 year: 2002 end-page: 404 ident: bib4 article-title: Efficacy of donepezil on behavioral symptoms in patient with moderate to severe Alzheimer's disease publication-title: Int Psychogeriatr – volume: 66 start-page: 1612 year: 2005 end-page: 1613 ident: bib7 article-title: Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies publication-title: J Clin Psychiatry – volume: 32 start-page: 1516 year: 2008 end-page: 1520 ident: bib2 article-title: Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex publication-title: Prog Neuro-Psychopharmacol Biol Psychiatr – volume: Vol.25 start-page: 313 year: 2002 end-page: 317 ident: bib15 article-title: Donepezil for treatment of behavioral symptoms in patients with Alzheimer's disease publication-title: Clin Neuropharmacol – volume: 12 start-page: 63 year: 1965 end-page: 70 ident: bib24 article-title: A self-rating depression scale publication-title: Arch Gen Psychiatry – volume: 53 start-page: 471 year: 1999 end-page: 481 ident: bib5 article-title: Development of a functional measure for persons with Alzheimer's disease: the disability assessment for dementia publication-title: Am J Occup Ther – volume: 13 start-page: 5 year: 2001 end-page: 21 ident: bib11 article-title: Role of serotonin in the behavioral and psychological symptoms dementia publication-title: J Neuropsychiatry Clin Neurosci – volume: 66 start-page: 248 year: 2005 end-page: 252 ident: bib8 article-title: A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients publication-title: J Clin Psychiatry – volume: 24 start-page: 653 year: 1988 end-page: 659 ident: bib16 article-title: Functional assessment staging (FAST) publication-title: Psychopharmacol Bull – volume: 353 start-page: 2335 year: 2005 end-page: 2341 ident: bib22 article-title: Risk of death in elderly users of conventional vs. atypical antipsychotic medications publication-title: N Engl J Med – volume: 61 start-page: 1 year: 2009 ident: 10.1016/j.pnpbp.2010.02.013_bib9 article-title: Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats publication-title: J Pharm Pharmacol doi: 10.1211/jpp.61.09.0016 – volume: 20 start-page: 649 year: 1980 ident: 10.1016/j.pnpbp.2010.02.013_bib23 article-title: Relatives of the impaired elderly: correlates of feelings of burden publication-title: Gerontologist doi: 10.1093/geront/20.6.649 – volume: 353 start-page: 2335 year: 2005 ident: 10.1016/j.pnpbp.2010.02.013_bib22 article-title: Risk of death in elderly users of conventional vs. atypical antipsychotic medications publication-title: N Engl J Med doi: 10.1056/NEJMoa052827 – volume: 12 start-page: 191 issue: 2 year: 2009 ident: 10.1016/j.pnpbp.2010.02.013_bib13 article-title: A randomized crossover study of a traditional Japanese medicine (kampo) “Yokukansan” in the treatment of the behavioral and psychological symptoms of dementia publication-title: Int J Neuropsychopharmacol doi: 10.1017/S146114570800970X – volume: 47 start-page: 257 issue: Suppl year: 2008 ident: 10.1016/j.pnpbp.2010.02.013_bib21 article-title: Partial agonistic effects for serotonin 1A receptors of yokukansan, a traditional Japanese medicine publication-title: Bull Jpn Soc Neurochem – volume: 13 start-page: 5 year: 2001 ident: 10.1016/j.pnpbp.2010.02.013_bib11 article-title: Role of serotonin in the behavioral and psychological symptoms dementia publication-title: J Neuropsychiatry Clin Neurosci doi: 10.1176/appi.neuropsych.13.1.5 – volume: 12 start-page: 63 year: 1965 ident: 10.1016/j.pnpbp.2010.02.013_bib24 article-title: A self-rating depression scale publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.1965.01720310065008 – volume: 8 start-page: 114 year: 2008 ident: 10.1016/j.pnpbp.2010.02.013_bib19 article-title: Post-marketing survey of donepezil hydrochloride in Japanese patient with Alzheimer's disease with behavioral and psychological symptoms of dementia (BPSD) publication-title: Psychogeriatrics doi: 10.1111/j.1479-8301.2008.00250.x – volume: 32 start-page: 1516 year: 2008 ident: 10.1016/j.pnpbp.2010.02.013_bib2 article-title: Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex publication-title: Prog Neuro-Psychopharmacol Biol Psychiatr doi: 10.1016/j.pnpbp.2008.05.010 – volume: 66 start-page: 1612 issue: 12 year: 2005 ident: 10.1016/j.pnpbp.2010.02.013_bib7 article-title: Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies publication-title: J Clin Psychiatry doi: 10.4088/JCP.v66n1219a – volume: 5 start-page: 94 year: 2005 ident: 10.1016/j.pnpbp.2010.02.013_bib20 article-title: Dementia caregivers' burdens and use of public services publication-title: Geriatr Gerontol Internat doi: 10.1111/j.1447-0594.2005.00274.x – volume: 44 start-page: 2308 year: 1994 ident: 10.1016/j.pnpbp.2010.02.013_bib1 article-title: The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia publication-title: Neurology doi: 10.1212/WNL.44.12.2308 – volume: 146 start-page: 775 year: 2007 ident: 10.1016/j.pnpbp.2010.02.013_bib6 article-title: Antipsychotic drug use and mortality in older adults with dementia publication-title: Ann Intern Med doi: 10.7326/0003-4819-146-11-200706050-00006 – volume: 159 start-page: 1397 year: 2009 ident: 10.1016/j.pnpbp.2010.02.013_bib10 article-title: Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells publication-title: Neuroscience doi: 10.1016/j.neuroscience.2009.02.004 – volume: 176 start-page: 627 year: 2007 ident: 10.1016/j.pnpbp.2010.02.013_bib17 article-title: Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients publication-title: CMAJ doi: 10.1503/cmaj.061250 – volume: 12 start-page: 189 year: 1975 ident: 10.1016/j.pnpbp.2010.02.013_bib3 article-title: “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician publication-title: J Psychiatr Res doi: 10.1016/0022-3956(75)90026-6 – volume: 14 start-page: 389 year: 2002 ident: 10.1016/j.pnpbp.2010.02.013_bib4 article-title: Efficacy of donepezil on behavioral symptoms in patient with moderate to severe Alzheimer's disease publication-title: Int Psychogeriatr doi: 10.1017/S104161020200858X – volume: 53 start-page: 230 year: 2008 ident: 10.1016/j.pnpbp.2010.02.013_bib18 article-title: Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan publication-title: Neurochem Int doi: 10.1016/j.neuint.2008.07.009 – volume: 66 start-page: 248 issue: 2 year: 2005 ident: 10.1016/j.pnpbp.2010.02.013_bib8 article-title: A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients publication-title: J Clin Psychiatry doi: 10.4088/JCP.v66n0214 – volume: 53 start-page: 471 year: 1999 ident: 10.1016/j.pnpbp.2010.02.013_bib5 article-title: Development of a functional measure for persons with Alzheimer's disease: the disability assessment for dementia publication-title: Am J Occup Ther doi: 10.5014/ajot.53.5.471 – volume: Vol.25 start-page: 313 issue: No.6 year: 2002 ident: 10.1016/j.pnpbp.2010.02.013_bib15 article-title: Donepezil for treatment of behavioral symptoms in patients with Alzheimer's disease publication-title: Clin Neuropharmacol doi: 10.1097/00002826-200211000-00007 – volume: B 19 start-page: 151 year: 1995 ident: 10.1016/j.pnpbp.2010.02.013_bib12 article-title: Evaluation with receptor binding assay on the water extracts of ten CNS-active Chinese herbal drugs – volume: 33 start-page: 308 year: 2009 ident: 10.1016/j.pnpbp.2010.02.013_bib14 article-title: Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease publication-title: Prog Neuropsychopharmacol Biol Psychiatry doi: 10.1016/j.pnpbp.2008.12.008 – volume: 24 start-page: 653 year: 1988 ident: 10.1016/j.pnpbp.2010.02.013_bib16 article-title: Functional assessment staging (FAST) publication-title: Psychopharmacol Bull |
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| SubjectTerms | Adult and adolescent clinical studies Aged Aged, 80 and over Alzheimer's disease Behavioral and psychological symptoms of dementia (BPSD) Behavioral Symptoms - drug therapy Behavioral Symptoms - etiology Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia - complications Dementia - drug therapy Drugs, Chinese Herbal - therapeutic use Female Humans Male Medical sciences Neurology Neuropharmacology Neuropsychological Tests NPI Organic mental disorders. Neuropsychology Pharmacology. Drug treatments Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Traditional Japanese medicine (kampo medicine) Treatment Outcome Yokukansan |
| Title | Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer's disease |
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