A noncanonical role of NOD-like receptor NLRP14 in PGCLC differentiation and spermatogenesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 36; pp. 22237 - 22248
• Main Authors: Yin, Yike, Cao, Shiyu, Fu, Huancheng, Fan, Xueying, Xiong, Jingfei, Huang, Qiuyue, Liu, Yu, Xie, Kun, Meng, Tie-Gang, Liu, Yuliang, Tang, Dan, Yang, Tingting, Dong, Biao, Qi, Shiqian, Nie, Ling, Xu, Wenming, Li, Fuping, Dai, Lunzhi, Sun, Qing-Yuan, Li, Zhonghan
• Format: Journal Article
• Language: English
• Published: Washington National Academy of Sciences 08.09.2020
• Subjects: Biological Sciences; Cell differentiation; Differentiation (biology); Inflammasomes; Male sterility; Meiosis; Nuclear transport; Oligozoospermia; Proteasomes; Receptors; Recruitment; Reproductive failure; Spermatogenesis; Stem cell transplantation; Stem cells; Translocation

NOD-like receptors (NLRs) are traditionally recognized as major inflammasome components. The role of NLRs in germ cell differentiation and reproduction is not known. Here, we identified the gonadspecific Nlrp14 as a pivotal regulator in primordial germ cell-like cell (PGCLC) differentiation in vitro...