Relationship of Dietary Protein and Soy Isoflavones to Serum IGF-1 and IGF Binding Proteins in the Prostate Cancer Lifestyle Trial

• Published in: Nutrition and cancer Vol. 58; no. 1; pp. 35 - 42
• Main Authors: Dewell, A, Weidner, G, Sumner, M.D, Barnard, R.J, Marlin, R.O, Daubenmier, J.J, Chi, C, Carroll, P.R, Ornish, D
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Taylor & Francis Group 01.01.2007; Taylor& Francis
• Subjects: anticarcinogenic activity; apoptosis; Biological and medical sciences; Biomarkers - blood; cell proliferation; diet; dietary protein; Dietary Proteins - administration & dosage; Dietary Proteins - metabolism; disease prevention; Diseases of the digestive system; Epidemiology; essential amino acids; Humans; insulin-like growth factor binding proteins; Insulin-Like Growth Factor Binding Proteins - metabolism; insulin-like growth factor I; Insulin-Like Growth Factor I - metabolism; isoflavones; Isoflavones - administration & dosage; Isoflavones - metabolism; Life Style; lifestyle; low fat diet; Male; Medical sciences; men; nutrient intake; Other treatments; plant source protein; Prostate Cancer Lifestyle Trial; prostatic neoplasms; Prostatic Neoplasms - blood; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - metabolism; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Risk Factors; Soy Foods; soy protein; soybean products; Soybean Proteins - administration & dosage; Soybean Proteins - metabolism; Treatment. General aspects; Tumors; vegetarian diet; very low fat diet; Human; Isoflavone; Urinary system disease; Prostate disease; Nutrition; Malignant tumor; Insulin like growth factor 1; Serum protein; Feeding; Soy protein; Binding protein; Diet therapy; Clinical trial; Male genital diseases; Prostate cancer; Food; Life style

High levels of insulin-like growth factor 1 (IGF-1) are associated with increased risk of prostate cancer, whereas increased levels of some of its binding proteins (IGFBPs) seem to be protective. High intakes of dietary protein, especially animal and soy protein, appear to increase IGF-1. However, s...