The Human Skin Barrier Is Organized as Stacked Bilayers of Fully Extended Ceramides with Cholesterol Molecules Associated with the Ceramide Sphingoid Moiety

• Published in: Journal of investigative dermatology Vol. 132; no. 9; pp. 2215 - 2225
• Main Authors: Iwai, Ichiro, Han, HongMei, Hollander, Lianne den, Svensson, Stina, Öfverstedt, Lars-Göran, Anwar, Jamshed, Brewer, Jonathan, Bloksgaard, Maria, Laloeuf, Aurelie, Nosek, Daniel, Masich, Sergej, Bagatolli, Luis A., Skoglund, Ulf, Norlén, Lars
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2012; Nature Publishing Group; Elsevier Limited
• Subjects: Adult; Biological and medical sciences; Ceramides - chemistry; Cholesterol - chemistry; Dermatologi och venereologi; Dermatology; Dermatology and Venereal Diseases; Humans; Lipid Bilayers - chemistry; Male; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Permeability; Skin - chemistry; Skin - ultrastructure; Sphingolipids - chemistry; Human; Sphingolipid; Ceramide; Skin; Dermatology; Cholesterol

The skin barrier is fundamental to terrestrial life and its evolution; it upholds homeostasis and protects against the environment. Skin barrier capacity is controlled by lipids that fill the extracellular space of the skin's surface layer—the stratum corneum. Here we report on the determinatio...