H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductase

• Published in: The Journal of biological chemistry Vol. 292; no. 28; pp. 11641 - 11649
• Main Authors: Landry, Aaron P., Ballou, David P., Banerjee, Ruma
• Format: Journal Article
• Language: English
• Published: 11200 Rockville Pike, Suite 302, Rockville, MD 20852-3110, U.S.A Elsevier Inc 14.07.2017; American Society for Biochemistry and Molecular Biology
• Subjects: enzyme kinetics; Enzymology; flavin; flavin adenine dinucleotide (FAD); glutathione; hydrogen sulfide; oxidation-reduction (redox); pre-steady-state kinetics; flavin adenine dinucleotide (FAD); pre-steady-state kinetics; hydrogen sulfide; oxidation-reduction (redox); glutathione; enzyme kinetics; flavin

Buildup of hydrogen sulfide (H2S), which functions as a signaling molecule but is toxic at high concentrations, is averted by its efficient oxidation by the mitochondrial sulfide oxidation pathway. The first step in this pathway is catalyzed by a flavoprotein, sulfide quinone oxidoreductase (SQR), w...