Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay

• Published in: Mutagenesis Vol. 31; no. 3; pp. 287 - 296
• Main Authors: Guo, Xiaoqing, Heflich, Robert H., Dial, Stacey L., Richter, Patricia A., Moore, Martha M., Mei, Nan
• Format: Journal Article
• Language: English
• Published: England 01.05.2016
• Subjects: Activation, Metabolic; Aminobiphenyl Compounds - metabolism; Aminobiphenyl Compounds - toxicity; Animals; Benzo(a)pyrene - metabolism; Benzo(a)pyrene - toxicity; Cadmium Chloride - toxicity; Carcinogens - toxicity; Cell Line, Tumor; DNA Damage; DNA, Neoplasm - drug effects; DNA, Neoplasm - metabolism; Lymphoma; Mice; Mutagenicity Tests; Mutagens - toxicity; Nitrosamines - metabolism; Nitrosamines - toxicity; Quinolines - metabolism; Quinolines - toxicity; Rats; Smoke - analysis

Quantifying health-related biological effects, like genotoxicity, could provide a way of distinguishing between tobacco products. In order to develop tools for using genotoxicty data to quantitatively evaluate the risk of tobacco products, we tested five carcinogens found in cigarette smoke, 4-amino...