Review of potentials and limitations of indirect approaches for estimating reference limits/intervals of quantitative procedures in laboratory medicine

• Published in: Journal of laboratory medicine Vol. 45; no. 2; pp. 35 - 53
• Main Authors: Haeckel, Rainer, Wosniok, Werner, Streichert, Thomas
• Format: Journal Article
• Language: English
• Published: De Gruyter 01.04.2021
• Subjects: data mining; indirect reference limits; reference intervals

Reference intervals (RIs) can be determined by direct and indirect procedures. Both approaches identify a reference population from which the RIs are defined. The crucial difference between direct and indirect methods is that direct methods select particular individuals after individual anamnesis an...