Comparison of double (360 mg) ticagrelor loading dose with standard (60 mg) prasugrel loading dose in ST-elevation myocardial infarction patients: The Rapid Activity of Platelet Inhibitor Drugs (RAPID) primary PCI 2 study

• Published in: The American heart journal Vol. 167; no. 6; pp. 909 - 914
• Main Authors: Parodi, Guido, Bellandi, Benedetta, Valenti, Renato, Migliorini, Angela, Marcucci, Rossella, Carrabba, Nazario, Giurlani, Letizia, Gensini, Gian Franco, Abbate, Rosanna, Antoniucci, David
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.06.2014; Elsevier Limited
• Subjects: Adenosine - analogs & derivatives; Adenosine - therapeutic use; Aged; Aspirin; Aspirin - therapeutic use; Blood platelets; Body mass index; Cardiovascular; Cardiovascular disease; Combined Modality Therapy; Coronary vessels; Diabetes; Dose-Response Relationship, Drug; Drug dosages; Drug therapy; Fees & charges; Female; Heart attacks; Humans; Intubation; Male; Middle Aged; Myocardial Infarction - drug therapy; Myocardial Infarction - therapy; Percutaneous Coronary Intervention - methods; Piperazines - therapeutic use; Platelet Activation; Platelet Aggregation Inhibitors - therapeutic use; Prasugrel Hydrochloride; Premedication - methods; Purinergic P2Y Receptor Antagonists - therapeutic use; Thiophenes - therapeutic use; Thrombosis; Time Factors; Treatment Outcome; Variables

In ST-elevation myocardial infarction (STEMI) patients, residual platelet reactivity soon after a loading dose (LD) of prasugrel or ticagrelor is higher than that reported for healthy volunteers or subjects with stable coronary artery disease; and the majority of primary percutaneous coronary interv...