Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)

• Published in: International journal of molecular medicine Vol. 52; no. 2; p. 1
• Main Authors: Shao, Li-Hua, Zhu, Li, Wang, Meng, Ning, Yue, Chen, Feng-Qin, Gao, Xia-Qing, Yang, Chun-Ting, Wang, Hong-Wei, Li, Hai-Long
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.08.2023; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Amino acids; Apoptosis; Apoptosis - genetics; Autophagy; Autophagy - genetics; Breast cancer; Cancer; Cancer therapies; Care and treatment; Cell Death; Chemotherapy; Chromosomal proteins; Development and progression; DNA damage; Drug resistance; Drug resistance in microorganisms; Ferroptosis; Genes; Health aspects; HMGB1 Protein - genetics; Homeostasis; Humans; Immunotherapy; Inflammation; Leukemia; Liver cancer; Metastasis; Mitochondrial DNA; Multidrug resistant organisms; Natural products; Neoplasms - drug therapy; Neoplasms - genetics; Oncology, Experimental; Proteins; Review; RNA; Tumorigenesis; Tumors; Canada; China; pyroptosis; ferroptosis; nanoparticles; non‑coding RNA; tumor multidrug resistance; apoptosis and autophagy; high mobility group box 1; traditional Chinese medicine

Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated th...