Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)
Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated th...
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Published in | International journal of molecular medicine Vol. 52; no. 2; p. 1 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Spandidos Publications
01.08.2023
Spandidos Publications UK Ltd D.A. Spandidos |
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Abstract | Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated that HMGB1 functions as a 'double‑edged sword' that plays both pro‑ and anti‑tumor roles in the development and progression of multiple types of cancer. HMGB1 has also been found to be a key regulator of several cell death and signaling pathways, and is involved in MDR by mediating cell autophagy and apoptosis, ferroptosis, pyroptosis and multiple signaling pathways. Additionally, HMGB1 is regulated by a variety of non‑coding RNAs (ncRNAs), such as microRNAs, long ncRNAs and circular RNAs that are involved in MDR. Thus far, studies have been conducted to identify strategies with which to overcome HMGB1‑mediated MDR by the targeted silencing of HMGB1 and the targeted interference of HMGB1 expression using drugs and ncRNAs. Therefore, HMGB1 is closely associated with tumor MDR and is a promising therapeutic target. |
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AbstractList | Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated that HMGB1 functions as a 'double‑edged sword' that plays both pro‑ and anti‑tumor roles in the development and progression of multiple types of cancer. HMGB1 has also been found to be a key regulator of several cell death and signaling pathways, and is involved in MDR by mediating cell autophagy and apoptosis, ferroptosis, pyroptosis and multiple signaling pathways. Additionally, HMGB1 is regulated by a variety of non‑coding RNAs (ncRNAs), such as microRNAs, long ncRNAs and circular RNAs that are involved in MDR. Thus far, studies have been conducted to identify strategies with which to overcome HMGB1‑mediated MDR by the targeted silencing of HMGB1 and the targeted interference of HMGB1 expression using drugs and ncRNAs. Therefore, HMGB1 is closely associated with tumor MDR and is a promising therapeutic target. Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated that HMGB1 functions as a 'double-edged sword' that plays both pro- and anti-tumor roles in the development and progression of multiple types of cancer. HMGB1 has also been found to be a key regulator of several cell death and signaling pathways, and is involved in MDR by mediating cell autophagy and apoptosis, ferroptosis, pyroptosis and multiple signaling pathways. Additionally, HMGB1 is regulated by a variety of non-coding RNAs (ncRNAs), such as microRNAs, long ncRNAs and circular RNAs that are involved in MDR. Thus far, studies have been conducted to identify strategies with which to overcome HMGB1-mediated MDR by the targeted silencing of HMGB1 and the targeted interference of HMGB1 expression using drugs and ncRNAs. Therefore, HMGB1 is closely associated with tumor MDR and is a promising therapeutic target. Key words: tumor multidrug resistance, high mobility group box 1, apoptosis and autophagy, pyroptosis, ferroptosis, non-coding RNA, traditional Chinese medicine, nanoparticles |
ArticleNumber | 69 |
Audience | Academic |
Author | Ning, Yue Shao, Li-Hua Zhu, Li Wang, Meng Wang, Hong-Wei Gao, Xia-Qing Li, Hai-Long Chen, Feng-Qin Yang, Chun-Ting |
AuthorAffiliation | 2 Emergency Department, Minda Hospital of Hubei Minzu University, Enshi, Hubei 445000 3 Department of Clinical Laboratory, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730050, P.R. China 4 Department of Geriatrics, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730050, P.R. China 1 Department of Internal Medicine, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000 |
AuthorAffiliation_xml | – name: 4 Department of Geriatrics, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730050, P.R. China – name: 3 Department of Clinical Laboratory, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730050, P.R. China – name: 1 Department of Internal Medicine, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000 – name: 2 Emergency Department, Minda Hospital of Hubei Minzu University, Enshi, Hubei 445000 |
Author_xml | – sequence: 1 givenname: Li-Hua surname: Shao fullname: Shao, Li-Hua organization: Department of Internal Medicine, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China – sequence: 2 givenname: Li surname: Zhu fullname: Zhu, Li organization: Emergency Department, Minda Hospital of Hubei Minzu University, Enshi, Hubei 445000, P.R. China – sequence: 3 givenname: Meng surname: Wang fullname: Wang, Meng organization: Department of Internal Medicine, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China – sequence: 4 givenname: Yue surname: Ning fullname: Ning, Yue organization: Department of Internal Medicine, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China – sequence: 5 givenname: Feng-Qin surname: Chen fullname: Chen, Feng-Qin organization: Emergency Department, Minda Hospital of Hubei Minzu University, Enshi, Hubei 445000, P.R. China – sequence: 6 givenname: Xia-Qing surname: Gao fullname: Gao, Xia-Qing organization: Department of Internal Medicine, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China – sequence: 7 givenname: Chun-Ting surname: Yang fullname: Yang, Chun-Ting organization: Department of Internal Medicine, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China – sequence: 8 givenname: Hong-Wei surname: Wang fullname: Wang, Hong-Wei organization: Department of Clinical Laboratory, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730050, P.R. China – sequence: 9 givenname: Hai-Long surname: Li fullname: Li, Hai-Long organization: Department of Internal Medicine, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, P.R. China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/37387415$$D View this record in MEDLINE/PubMed |
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Copyright | COPYRIGHT 2023 Spandidos Publications Copyright Spandidos Publications UK Ltd. 2023 Copyright: © Shao et al. 2023 |
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Keywords | pyroptosis ferroptosis nanoparticles non‑coding RNA tumor multidrug resistance apoptosis and autophagy high mobility group box 1 traditional Chinese medicine |
Language | English |
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Snippet | Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high... |
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SubjectTerms | Amino acids Apoptosis Apoptosis - genetics Autophagy Autophagy - genetics Breast cancer Cancer Cancer therapies Care and treatment Cell Death Chemotherapy Chromosomal proteins Development and progression DNA damage Drug resistance Drug resistance in microorganisms Ferroptosis Genes Health aspects HMGB1 Protein - genetics Homeostasis Humans Immunotherapy Inflammation Leukemia Liver cancer Metastasis Mitochondrial DNA Multidrug resistant organisms Natural products Neoplasms - drug therapy Neoplasms - genetics Oncology, Experimental Proteins Review RNA Tumorigenesis Tumors |
Title | Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review) |
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