Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)

Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated th...

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Published inInternational journal of molecular medicine Vol. 52; no. 2; p. 1
Main Authors Shao, Li-Hua, Zhu, Li, Wang, Meng, Ning, Yue, Chen, Feng-Qin, Gao, Xia-Qing, Yang, Chun-Ting, Wang, Hong-Wei, Li, Hai-Long
Format Journal Article
LanguageEnglish
Published Greece Spandidos Publications 01.08.2023
Spandidos Publications UK Ltd
D.A. Spandidos
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Abstract Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated that HMGB1 functions as a 'double‑edged sword' that plays both pro‑ and anti‑tumor roles in the development and progression of multiple types of cancer. HMGB1 has also been found to be a key regulator of several cell death and signaling pathways, and is involved in MDR by mediating cell autophagy and apoptosis, ferroptosis, pyroptosis and multiple signaling pathways. Additionally, HMGB1 is regulated by a variety of non‑coding RNAs (ncRNAs), such as microRNAs, long ncRNAs and circular RNAs that are involved in MDR. Thus far, studies have been conducted to identify strategies with which to overcome HMGB1‑mediated MDR by the targeted silencing of HMGB1 and the targeted interference of HMGB1 expression using drugs and ncRNAs. Therefore, HMGB1 is closely associated with tumor MDR and is a promising therapeutic target.
AbstractList Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated that HMGB1 functions as a 'double‑edged sword' that plays both pro‑ and anti‑tumor roles in the development and progression of multiple types of cancer. HMGB1 has also been found to be a key regulator of several cell death and signaling pathways, and is involved in MDR by mediating cell autophagy and apoptosis, ferroptosis, pyroptosis and multiple signaling pathways. Additionally, HMGB1 is regulated by a variety of non‑coding RNAs (ncRNAs), such as microRNAs, long ncRNAs and circular RNAs that are involved in MDR. Thus far, studies have been conducted to identify strategies with which to overcome HMGB1‑mediated MDR by the targeted silencing of HMGB1 and the targeted interference of HMGB1 expression using drugs and ncRNAs. Therefore, HMGB1 is closely associated with tumor MDR and is a promising therapeutic target.
Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated that HMGB1 functions as a 'double-edged sword' that plays both pro- and anti-tumor roles in the development and progression of multiple types of cancer. HMGB1 has also been found to be a key regulator of several cell death and signaling pathways, and is involved in MDR by mediating cell autophagy and apoptosis, ferroptosis, pyroptosis and multiple signaling pathways. Additionally, HMGB1 is regulated by a variety of non-coding RNAs (ncRNAs), such as microRNAs, long ncRNAs and circular RNAs that are involved in MDR. Thus far, studies have been conducted to identify strategies with which to overcome HMGB1-mediated MDR by the targeted silencing of HMGB1 and the targeted interference of HMGB1 expression using drugs and ncRNAs. Therefore, HMGB1 is closely associated with tumor MDR and is a promising therapeutic target. Key words: tumor multidrug resistance, high mobility group box 1, apoptosis and autophagy, pyroptosis, ferroptosis, non-coding RNA, traditional Chinese medicine, nanoparticles
ArticleNumber 69
Audience Academic
Author Ning, Yue
Shao, Li-Hua
Zhu, Li
Wang, Meng
Wang, Hong-Wei
Gao, Xia-Qing
Li, Hai-Long
Chen, Feng-Qin
Yang, Chun-Ting
AuthorAffiliation 2 Emergency Department, Minda Hospital of Hubei Minzu University, Enshi, Hubei 445000
3 Department of Clinical Laboratory, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730050, P.R. China
4 Department of Geriatrics, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730050, P.R. China
1 Department of Internal Medicine, First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000
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Issue 2
Keywords pyroptosis
ferroptosis
nanoparticles
non‑coding RNA
tumor multidrug resistance
apoptosis and autophagy
high mobility group box 1
traditional Chinese medicine
Language English
License This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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Zhao (key20230810105114_b39-ijmm-52-2-05272) 2021; 40
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Jiang (key20230810105114_b194-ijmm-52-2-05272) 2021; 33
Luo (key20230810105114_b148-ijmm-52-2-05272) 2021; 17
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Liu (key20230810105114_b79-ijmm-52-2-05272) 2017; 12
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Snippet Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high...
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StartPage 1
SubjectTerms Amino acids
Apoptosis
Apoptosis - genetics
Autophagy
Autophagy - genetics
Breast cancer
Cancer
Cancer therapies
Care and treatment
Cell Death
Chemotherapy
Chromosomal proteins
Development and progression
DNA damage
Drug resistance
Drug resistance in microorganisms
Ferroptosis
Genes
Health aspects
HMGB1 Protein - genetics
Homeostasis
Humans
Immunotherapy
Inflammation
Leukemia
Liver cancer
Metastasis
Mitochondrial DNA
Multidrug resistant organisms
Natural products
Neoplasms - drug therapy
Neoplasms - genetics
Oncology, Experimental
Proteins
Review
RNA
Tumorigenesis
Tumors
Title Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)
URI https://www.ncbi.nlm.nih.gov/pubmed/37387415
https://www.proquest.com/docview/2848086864
https://pubmed.ncbi.nlm.nih.gov/PMC10373125
Volume 52
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