Quantitative analysis of clopidogrel bisulphate and aspirin by first derivative spectrophotometric method in tablets
A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopido...
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Published in | Indian journal of pharmaceutical sciences Vol. 72; no. 6; pp. 825 - 828 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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India
Medknow Publications and Media Pvt. Ltd
01.11.2010
Medknow Publications & Media Pvt. Ltd Medknow Publications |
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Abstract | A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopidogrel bisulphate and 211.3 nm (zero cross point of clopidogrel bisulphate) for aspirin.Both the drugs obeyed linearity in the concentration range of 5.0 μg/ml to 25.0 μg/ml (correlation coefficient r(2)<1). No interference was found between both determined constituents and those of matrix. The method was validated statistically and recovery studies were carried out to confirm the accuracy of the method. |
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AbstractList | A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopidogrel bisulphate and 211.3 nm (zero cross point of clopidogrel bisulphate) for aspirin.Both the drugs obeyed linearity in the concentration range of 5.0 μg/ml to 25.0 μg/ml (correlation coefficient r(2)<1). No interference was found between both determined constituents and those of matrix. The method was validated statistically and recovery studies were carried out to confirm the accuracy of the method. A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopidogrel bisulphate and 211.3 nm (zero cross point of clopidogrel bisulphate) for aspirin.Both the drugs obeyed linearity in the concentration range of 5.0 μg/ml to 25.0 μg/ml (correlation coefficient r 2 <1). No interference was found between both determined constituents and those of matrix. The method was validated statistically and recovery studies were carried out to confirm the accuracy of the method. |
Audience | Academic |
Author | Sakarkar, D M Gabhane, K B Game, Madhuri D |
AuthorAffiliation | 1 Sudhakarrao Naik Institute of Pharmacy, Pusad - 445 204, Maharashtra, India Vidyabharati College of Pharmacy, C. K. Naidu road, Camp, Amravati - 444 602, India |
AuthorAffiliation_xml | – name: 1 Sudhakarrao Naik Institute of Pharmacy, Pusad - 445 204, Maharashtra, India – name: Vidyabharati College of Pharmacy, C. K. Naidu road, Camp, Amravati - 444 602, India |
Author_xml | – sequence: 1 givenname: Madhuri D surname: Game fullname: Game, Madhuri D organization: Vidyabharati College of Pharmacy, C. K. Naidu road, Camp, Amravati - 444 602, India – sequence: 2 givenname: K B surname: Gabhane fullname: Gabhane, K B – sequence: 3 givenname: D M surname: Sakarkar fullname: Sakarkar, D M |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/21969765$$D View this record in MEDLINE/PubMed |
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Copyright | COPYRIGHT 2010 Medknow Publications and Media Pvt. Ltd. Copyright Medknow Publications & Media Pvt Ltd Nov 2010 Copyright: © Indian Journal of Pharmaceutical Sciences 2010 |
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Keywords | derivative spectrophotometry Aspirin clopidogrel bisulphate drug analysis |
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SubjectTerms | Analysis Analytical chemistry Aspirin Calibration Clopidogrel Health aspects Methods Properties Short Communications |
Title | Quantitative analysis of clopidogrel bisulphate and aspirin by first derivative spectrophotometric method in tablets |
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