Quantitative analysis of clopidogrel bisulphate and aspirin by first derivative spectrophotometric method in tablets

A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopido...

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Published inIndian journal of pharmaceutical sciences Vol. 72; no. 6; pp. 825 - 828
Main Authors Game, Madhuri D, Gabhane, K B, Sakarkar, D M
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.11.2010
Medknow Publications & Media Pvt. Ltd
Medknow Publications
Subjects
Analysis
Analytical chemistry
Aspirin
Calibration
Clopidogrel
Health aspects
Methods
Properties
Short Communications
India
derivative spectrophotometry
Aspirin
clopidogrel bisulphate
drug analysis
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Abstract A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopidogrel bisulphate and 211.3 nm (zero cross point of clopidogrel bisulphate) for aspirin.Both the drugs obeyed linearity in the concentration range of 5.0 μg/ml to 25.0 μg/ml (correlation coefficient r(2)<1). No interference was found between both determined constituents and those of matrix. The method was validated statistically and recovery studies were carried out to confirm the accuracy of the method.
AbstractList A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopidogrel bisulphate and 211.3 nm (zero cross point of clopidogrel bisulphate) for aspirin.Both the drugs obeyed linearity in the concentration range of 5.0 μg/ml to 25.0 μg/ml (correlation coefficient r(2)<1). No interference was found between both determined constituents and those of matrix. The method was validated statistically and recovery studies were carried out to confirm the accuracy of the method.
A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopidogrel bisulphate and 211.3 nm (zero cross point of clopidogrel bisulphate) for aspirin.Both the drugs obeyed linearity in the concentration range of 5.0 μg/ml to 25.0 μg/ml (correlation coefficient r 2 <1). No interference was found between both determined constituents and those of matrix. The method was validated statistically and recovery studies were carried out to confirm the accuracy of the method.
Audience Academic
Author Sakarkar, D M
Gabhane, K B
Game, Madhuri D
AuthorAffiliation 1 Sudhakarrao Naik Institute of Pharmacy, Pusad - 445 204, Maharashtra, India
Vidyabharati College of Pharmacy, C. K. Naidu road, Camp, Amravati - 444 602, India
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Copyright COPYRIGHT 2010 Medknow Publications and Media Pvt. Ltd.
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Issue 6
Keywords derivative spectrophotometry
Aspirin
clopidogrel bisulphate
drug analysis
Language English
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SubjectTerms Analysis
Analytical chemistry
Aspirin
Calibration
Clopidogrel
Health aspects
Methods
Properties
Short Communications
Title Quantitative analysis of clopidogrel bisulphate and aspirin by first derivative spectrophotometric method in tablets
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