In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit

• Published in: Antiviral research Vol. 160; pp. 109 - 117
• Main Authors: Noshi, Takeshi, Kitano, Mitsutaka, Taniguchi, Keiichi, Yamamoto, Atsuko, Omoto, Shinya, Baba, Keiko, Hashimoto, Takashi, Ishida, Kayo, Kushima, Yukihiro, Hattori, Kazunari, Kawai, Makoto, Yoshida, Ryu, Kobayashi, Masanori, Yoshinaga, Tomokazu, Sato, Akihiko, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi, Shishido, Takao, Naito, Akira
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2018
• Subjects: Baloxavir acid; Baloxavir marboxil; Cap-dependent endonuclease; Influenza virus; CENi; BXA; CEN; Baloxavir marboxil; vRNPs; Baloxavir acid; 3Ptap; Influenza virus; RdRp; BXM; SI; NAI; Cap-dependent endonuclease

Cap-dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and mediates the critical “cap-snatching” step of viral RNA transcription, which is considered to be a promising anti-influenza target. Here, we describe in vitro characterization of a novel CEN inhibitor, baloxavir ac...