The shared genomic architecture of human nucleolar organizer regions

• Published in: Genome research Vol. 23; no. 12; pp. 2003 - 2012
• Main Authors: Floutsakou, Ioanna, Agrawal, Saumya, Nguyen, Thong T, Seoighe, Cathal, Ganley, Austen R D, McStay, Brian
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.12.2013
• Subjects: Cell Line, Tumor; Cell Nucleolus - genetics; Centromere; Chromatin - genetics; Chromosomes, Human; DNA, Ribosomal - genetics; Genome, Human; HeLa Cells; Humans; Molecular Sequence Data; Nucleolus Organizer Region - genetics; Oligonucleotide Array Sequence Analysis; Ribosomes - genetics; Segmental Duplications, Genomic; Sequence Analysis, DNA; Transfection

The short arms of the five acrocentric human chromosomes harbor sequences that direct the assembly and function of the nucleolus, one of the key functional domains of the nucleus, yet they are absent from the current human genome assembly. Here we describe the genomic architecture of these human nuc...