Antibiofilm Effects of Macrolide Loaded Microneedle Patches: Prospects in Healing Infected Wounds

• Published in: Pharmaceutical research Vol. 38; no. 1; pp. 165 - 177
• Main Authors: Arshad, Muhammad Sohail, Zahra, Aleema Tehreem, Zafar, Saman, Zaman, Hussain, Akhtar, Ambreen, Ayaz, Muhammad Mazhar, Kucuk, Israfil, Maniruzzaman, Mohammed, Chang, Ming-Wei, Ahmad, Zeeshan
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2021; Springer; Springer Nature B.V
• Subjects: Antibiotics; Azithromycin; Biochemistry; Biofilms; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Calorimetry; Care and treatment; Dermis; Differential scanning calorimetry; Erythromycin; Escherichia coli; Follicles; Fourier analysis; Fourier transforms; Hyaluronic acid; Infrared spectroscopy; Medical Law; Pharmacology/Toxicology; Pharmacy; Polymers; Research Paper; Wound healing; Wounds and injuries; microneedles; azithromycin; transdermal; erythromycin; biofilm; macrolide

Aim The aim of this study was to fabricate polymeric microneedles, loaded with macrolides (erythromycin, azithromycin), using hyaluronic acid and polyvinyl pyrollidone. Methods These microneedles were fabricated using a vacuum micromolding technique. The integrity of the microneedle patches was stud...