lobSTR: A short tandem repeat profiler for personal genomes

• Published in: Genome research Vol. 22; no. 6; pp. 1154 - 1162
• Main Authors: Gymrek, Melissa, Golan, David, Rosset, Saharon, Erlich, Yaniv
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.06.2012
• Subjects: Algorithms; Electrophoresis - methods; Female; Genetic Variation; Genome, Human; Genomics - methods; HapMap Project; Humans; Male; Method; Microsatellite Repeats; Pedigree; Reproducibility of Results; Software

Short tandem repeats (STRs) have a wide range of applications, including medical genetics, forensics, and genetic genealogy. High-throughput sequencing (HTS) has the potential to profile hundreds of thousands of STR loci. However, mainstream bioinformatics pipelines are inadequate for the task. Thes...