Endothelin-1­induced cardiomyocyte hypertrophy is partly regulated by transcription factor II-F interacting C-terminal domain phosphatase of RNA polymerase II

• Published in: Life sciences (1973) Vol. 91; no. 13-14; pp. 572 - 577
• Main Authors: Sakai, Satoshi, Kimura, Taizo, Wang, Zheng, Shimojo, Nobutake, Maruyama, Hidekazu, Homma, Satoshi, Kuga, Keisuke, Yamaguchi, Iwao, Aonuma, Kazutaka, Miyauchi, Takashi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.10.2012
• Subjects: Animals; Animals, Newborn; Atrial Natriuretic Factor - genetics; Cardiac hypertrophy; Cardiomegaly - pathology; cardiomyocytes; CTD phosphatase; DNA-directed RNA polymerase; Endothelin-1; Endothelin-1 - metabolism; FCP1; Gene Expression Regulation; genes; genetic markers; Humans; hypertrophy; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Myosin Heavy Chains - genetics; Phosphoprotein Phosphatases - metabolism; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA; RNA - biosynthesis; RNA polymerase II; RNA Polymerase II - metabolism; surface area; Transcription Factor TFIIH - metabolism; transcription factors; Up-Regulation; Cardiac hypertrophy; CTD phosphatase; FCP1; RNA polymerase II; Endothelin-1

Cardiac hypertrophy is associated with the increase of total amount of RNA, which is in accordance with RNA polymerase II (RNAPII) activation via C-terminal domain (CTD) phosphorylation of the largest subunit of RNAPII. It has been demonstrated that endothelin-1 (ET-1) phosphorylates CTD at the hype...