Melatonin Augments the Expression of Core Transcription Factors in Aged and Alzheimer’s Patient Skin Fibroblasts

• Published in: Biology (Basel, Switzerland) Vol. 13; no. 9; p. 698
• Main Authors: Shukla, Mayuri, Duangrat, Raphiporn, Nopparat, Chutikorn, Sotthibundhu, Areechun, Govitrapong, Piyarat
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2024
• Subjects: adults; Advertising executives; Aging; Alzheimer's disease; Cell culture; Cell self-renewal; Cognitive ability; core transcription factors; Dementia disorders; Disease; DNA binding proteins; Embryo cells; Ethylenediaminetetraacetic acid; Fibroblasts; Gene regulation; Health aspects; Human subjects; humans; Investigations; Melatonin; Membranes; Neurodegeneration; Neurodegenerative diseases; Neurogenesis; Neurons; Neuroprotection; neuroprotective effect; Neurotoxicity; Oct-4 protein; Oct4; Older people; pathogenesis; patients; Penicillin; Pluripotency; Proteins; Senescence; Skin; Skin diseases; Sox2; Stem cells; therapeutics; Toxicity; Transcription factors; United States > US; Oct4; Sox2; fibroblasts; Alzheimer’s disease; Nanog; melatonin; core transcription factors

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. Altered neurogenesis and the appearance of AD pathological hallmarks are fundamental to this disease. SRY-Box transcription factor 2 (Sox2), octamer-binding transcription factor 4 (Oct4), and Nanog are a set of core transcription...