Correspondence of DNA Methylation Between Blood and Brain Tissue and Its Application to Schizophrenia Research

• Published in: Schizophrenia bulletin Vol. 42; no. 2; pp. 406 - 414
• Main Authors: Walton, Esther, Hass, Johanna, Liu, Jingyu, Roffman, Joshua L., Bernardoni, Fabio, Roessner, Veit, Kirsch, Matthias, Schackert, Gabriele, Calhoun, Vince, Ehrlich, Stefan
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.03.2016
• Subjects: Biomarkers - blood; Biomarkers - metabolism; Brain - metabolism; CpG Islands; DNA Methylation - physiology; Epigenesis, Genetic; Humans; Regular; Schizophrenia - blood; Schizophrenia - metabolism; DNA methylation; schizophrenia; correlation; brain; blood; cross-tissue

Given the difficulty of procuring human brain tissue, a key question in molecular psychiatry concerns the extent to which epigenetic signatures measured in more accessible tissues such as blood can serve as a surrogate marker for the brain. Here, we aimed (1) to investigate the blood-brain correspon...