Assessment of the frequency of SARS-CoV-2 Omicron variant escape from RNA-dependent RNA polymerase inhibitors and 3C-like protease inhibitors

• Published in: Antiviral research Vol. 216; p. 105671
• Main Authors: Takashita, Emi, Fujisaki, Seiichiro, Morita, Hiroko, Nagata, Shiho, Miura, Hideka, Nagashima, Mami, Watanabe, Shinji, Takeda, Makoto, Kawaoka, Yoshihiro, Hasegawa, Hideki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2023
• Subjects: Lufotrelvir; Molnupiravir; Nirmatrelvir; Remdesivir; Resistance; SARS-CoV-2; Resistance; Lufotrelvir; SARS-CoV-2; Remdesivir; Nirmatrelvir; Molnupiravir

The emergence and spread of antiviral-resistant SARS-CoV-2 is of great concern. In this study, we evaluated the propensity of Omicron variants to escape from RNA-dependent RNA polymerase (RdRP) inhibitors and 3C-like protease (3CLpro) inhibitors. SARS-CoV-2 Delta and Omicron variants were serially p...