CCL21 Chemokine Regulates Chemokine Receptor CCR7 Bearing Malignant Melanoma Cells

• Published in: Clinical cancer research Vol. 10; no. 7; pp. 2351 - 2358
• Main Authors: TAKEUCHI, Hiroya, FUJIMOTO, Akihide, TANAKA, Maki, YAMANO, Tomoki, HSUEH, Eddy, HOON, Dave S. B
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.04.2004
• Subjects: Antineoplastic agents; Biological and medical sciences; Cell Line, Tumor; Cell Movement; Chemokine CCL21; Chemokines - metabolism; Chemokines, CC - biosynthesis; Dendritic Cells - metabolism; DNA Primers - chemistry; Humans; Immunohistochemistry; Lasers; Ligands; Lymph Nodes - pathology; Lymphatic Metastasis; Medical sciences; Melanoma - pathology; Pharmacology. Drug treatments; Receptors, CCR7; Receptors, Chemokine - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA - metabolism; RNA, Messenger - metabolism; Transcription, Genetic; Tumors; Regulation(control); Chemokine receptor; Malignant tumor; CC chemokine; CCR7 chemokine receptor; Malignant melanoma

Purpose: The chemokine CC-ligand 21/secondary lymphoid tissue chemokine (CCL21/SLC) regulates the homing of naïve T cells and dendritic cells that express CC-chemokine receptor 7 (CCR7) from distant sites to lymphoid tissue such as lymph nodes. We hypothesized that CCL21/SLC regulates the migration...