Endometriosis may be associated with mitochondrial dysfunction in cumulus cells from subjects undergoing in vitro fertilization-intracytoplasmic sperm injection, as reflected by decreased adenosine triphosphate production

• Published in: Fertility and sterility Vol. 103; no. 2; pp. 347 - 352.e1
• Main Authors: Hsu, Albert L., Townsend, Paige M., Oehninger, Sergio, Castora, Frank J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2015
• Subjects: Adenosine Triphosphate - biosynthesis; Adult; Cohort Studies; cumulus cells; Cumulus Cells - metabolism; DNA, Mitochondrial - metabolism; Endometriosis; Endometriosis - diagnosis; Endometriosis - metabolism; Female; Fertilization in Vitro - methods; Humans; infertility; Internal Medicine; Male; mitochondria; Mitochondria - metabolism; Obstetrics and Gynecology; Pregnancy; Pregnancy Rate - trends; Prospective Studies; Sperm Injections, Intracytoplasmic - methods; Endometriosis; infertility; mitochondria; cumulus cells

To determine whether endometriosis is associated with mitochondrial dysfunction in cumulus (granulosa [GC]) cells of subjects undergoing IVF-intracytoplasmic sperm injection (ICSI). Prospective cohort study. An IVF clinic in a tertiary academic care center. Eleven women with endometriosis and 39 con...