Serum levels of RIPK3 and troponin I as potential biomarkers for predicting impaired left ventricular function in patients with myocardial infarction with ST segment elevation and normal troponin I levels prior percutaneous coronary intervention

• Published in: BioScience Trends Vol. 10; no. 4; pp. 294 - 299
• Main Authors: Ghenev, Peter I, Doneva, Jordanka G, Radeva, Temenuzhka R, Ivanov, Borislav D, Kirkorova, Arpine D, Valkov, Veselin D, Georgieva, Zhaneta T, Donev, Ivan S, Conev, Nikolay V, Kashlov, Javor K
• Format: Journal Article
• Language: English
• Published: Japan International Research and Cooperation Association for Bio & Socio-Sciences Advancement 2016
• Subjects: Aged; Biomarkers - blood; Female; Humans; left ventricular ejection fraction (LVEF); Male; marker; Middle Aged; Odds Ratio; percutaneous coronary intervention (PCI); Predictive Value of Tests; Prognosis; Receptor-interacting protein kinase 3 (RIPK3); Receptor-Interacting Protein Serine-Threonine Kinases - blood; ROC Curve; Sensitivity and Specificity; ST Elevation Myocardial Infarction - diagnosis; ST Elevation Myocardial Infarction - metabolism; ST Elevation Myocardial Infarction - physiopathology; Stroke Volume; Troponin I - blood; Ventricular Function, Left
• ISSN: 1881-7815; 1881-7823; 1881-7823
• DOI: 10.5582/bst.2016.01077

The current study examined the serum levels of receptor-interacting protein kinase 3 (RIPK3) in 51 patients with New York Heart Association (NYHA) class III-IV heart failure, 53 patients with myocardial infarction with ST elevation (STEMI), and 19 healthy subjects serving as a control group. An enzyme-linked immunoadsorbent assay (ELISA) was used to measure the levels of RIPK3 expression in serum. The area under the receiver operating characteristic curve (AUC) was then used to evaluate the predictive performance of RIPK3 and troponin I in patients with STEMI. In patients with normal levels of troponin I prior to percutaneous coronary intervention (PCI), serum levels of RIPK3 and troponin I after PCI were sufficient to differentiate patients with a preserved left ventricular ejection fraction (LVEF) from those with impaired left ventricular function after PCI (AUC = 0.780 (95% CI: 0.565-0.995, p = 0.043) with a sensitivity of 76.9% and a specificity of 71.4% vs. AUC = 0.735 (95% CI: 0.530-0.941, p = 0.038) with a sensitivity of 88.2% and a specificity of 63.6% at the optimal cutoff values, respectively). Moreover, elevated levels of troponin I after PCI were associated with an increased risk of an LVEF < 50% prior to discharge (odds ratio, 1.014; 95 % CI, 1.001 to 1.027; p = 0.03), while elevated levels of RIPK3 were not associated with such a risk. The current findings suggest that in patients with normal levels of troponin I prior to PCI, serum levels of RIPK3 and troponin I can serve as a potential marker to identify patients with a decreased LVEF, thus possibly allowing an early shift to more intensive therapy.