Elevated Myl9 reflects the Myl9-containing microthrombi in SARS-CoV-2–induced lung exudative vasculitis and predicts COVID-19 severity

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 119; no. 33; pp. 1 - 11
• Main Authors: Iwamura, Chiaki, Hirahara, Kiyoshi, Kiuchi, Masahiro, Ikehara, Sanae, Azuma, Kazuhiko, Shimada, Tadanaga, Kuriyama, Sachiko, Ohki, Syota, Yamamoto, Emiri, Inaba, Yosuke, Shiko, Yuki, Aoki, Ami, Kokubo, Kota, Hirasawa, Rui, Hishiya, Takahisa, Tsuji, Kaori, Nagaoka, Tetsutaro, Ishikawa, Satoru, Kojima, Akira, Mito, Haruki, Hase, Ryota, Kasahara, Yasunori, Kuriyama, Naohide, Tsukamoto, Tetsuya, Nakamura, Sukeyuki, Urushibara, Takashi, Kaneda, Satoru, Sakao, Seiichiro, Tobiume, Minoru, Suzuki, Yoshio, Tsujiwaki, Mitsuhiro, Kubo, Terufumi, Hasegawa, Tadashi, Nakase, Hiroshi, Nishida, Osamu, Takahashi, Kazuhisa, Baba, Komei, Iizumi, Yoko, Okazaki, Toshiya, Kimura, Motoko Y., Yoshino, Ichiro, Igari, Hidetoshi, Nakajima, Hiroshi, Suzuki, Takuji, Hanaoka, Hideki, Nakada, Taka-aki, Ikehara, Yuzuru, Yokote, Koutaro, Nakayama, Toshinori
• Format: Journal Article
• Language: English
• Published: Washington National Academy of Sciences 16.08.2022
• Subjects: Autopsies; Autopsy; Biological Sciences; Blood vessels; Coronaviruses; COVID-19; Emission analysis; Exudation; Field emission microscopy; Gene sequencing; Leukocytes (mononuclear); Lungs; Medical treatment; Monocytes; Myosin; Pathogenesis; Peripheral blood mononuclear cells; Respiratory diseases; Scanning electron microscopy; Severe acute respiratory syndrome coronavirus 2; Thrombospondin; Vasculitis; Viral diseases; X-ray spectroscopy

The mortality of coronavirus disease 2019 (COVID-19) is strongly correlated with pulmonary vascular pathology accompanied by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection–triggered immune dysregulation and aberrant activation of platelets. We combined histological analyses u...