Influence of the treatment with the antineoplastic agents 5-fluorouracil and cisplatin on the severity of experimental periodontitis in rats

• Published in: Supportive care in cancer Vol. 30; no. 3; pp. 1967 - 1980
• Main Authors: Novaes, Vivian Cristina Noronha, Ervolino, Edilson, Fernandes, Giovani Lopes, Cunha, Clara Possarle, Theodoro, Leticia Helena, Garcia, Valdir Gouveia, de Almeida, Juliano Milanezi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2022; Springer; Springer Nature B.V
• Subjects: Alveolar Bone Loss - drug therapy; Animals; Antineoplastic Agents - therapeutic use; Cancer; Chemotherapy; Cisplatin - therapeutic use; Cytotoxicity; Ethylenediaminetetraacetic acid; Fluorouracil; Fluorouracil - therapeutic use; Gum disease; Health aspects; Male; Medicine; Medicine & Public Health; Nursing; Nursing Research; Oncology; Original Article; Pain Medicine; Periodontitis; Periodontitis - drug therapy; Physiological aspects; Rats; Rats, Wistar; Rehabilitation Medicine; Rodents; Side effects; Tissue engineering; Periodontitis; Antineoplastic agents; Cisplatin; Alveolar bone loss; Fluorouracil

Purpose The determination on how antineoplastic agents interfere on the progression of periodontitis is critical for improvement and even development of novel therapeutic approaches for periodontal management. This study evaluated the influence of chemotherapy with 5-fluorouracil (5-FU) or cisplatin...