Rationale and design of the Aquapheresis Versus Intravenous Diuretics and Hospitalization for Heart Failure (AVOID-HF) trial

• Published in: The American heart journal Vol. 170; no. 3; pp. 471 - 482
• Main Authors: Costanzo, Maria Rosa, Negoianu, Daniel, Fonarow, Gregg C., Jaski, Brian E., Bart, Bradley A., Heywood, J. Thomas, Nabut, Jose L., Schollmeyer, Michael P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2015; Elsevier Limited
• Subjects: Aged; Blood pressure; Cardiovascular; Diuretics; Diuretics - administration & dosage; Dose-Response Relationship, Drug; Female; Fluids; Follow-Up Studies; Heart failure; Heart Failure - physiopathology; Heart Failure - therapy; Hospitalization; Hospitalization - statistics & numerical data; Humans; Infusions, Intravenous; Laboratories; Male; Medical prognosis; Mortality; Prospective Studies; Time Factors; Treatment Outcome; Ultrafiltration - methods; Urine

In patients hospitalized with acutely decompensated heart failure, unresolved signs and symptoms of fluid overload have been consistently associated with poor outcomes. Regardless of dosing and type of administration, intravenous loop diuretics have not reduced heart failure events or mortality in p...