Gene expression drives local adaptation in humans

• Published in: Genome research Vol. 23; no. 7; pp. 1089 - 1096
• Main Author: Fraser, Hunter B.
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.07.2013
• Subjects: Adaptation, Biological - genetics; Cell Line; DNA Damage; Gene Expression; Gene Expression Regulation; Humans; Polymorphism, Single Nucleotide; Regulatory Sequences, Nucleic Acid; Selection, Genetic

The molecular basis of adaptation—and, in particular, the relative roles of protein-coding versus gene expression changes—has long been the subject of speculation and debate. Recently, the genotyping of diverse human populations has led to the identification of many putative “local adaptations” that...