Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus

• Published in: mBio Vol. 5; no. 5; p. e01548
• Main Authors: Hevia, Arancha, Milani, Christian, López, Patricia, Cuervo, Adriana, Arboleya, Silvia, Duranti, Sabrina, Turroni, Francesca, González, Sonia, Suárez, Ana, Gueimonde, Miguel, Ventura, Marco, Sánchez, Borja, Margolles, Abelardo
• Format: Journal Article
• Language: English
• Published: United States American Society of Microbiology 30.09.2014; American Society for Microbiology
• Subjects: Adult; antibodies; antigens; Bacteroidetes - isolation & purification; Body Mass Index; Cross-Sectional Studies; Dietary Carbohydrates - administration & dosage; Dietary Fiber - administration & dosage; Dietary Proteins - administration & dosage; digestive system; DNA; Dysbiosis - complications; Dysbiosis - diagnosis; Dysbiosis - microbiology; Energy Intake; Feces - microbiology; Female; Firmicutes; Healthy Volunteers; Humans; intestinal microorganisms; Intestines - microbiology; Intestines - physiopathology; Life Style; lupus erythematosus; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - microbiology; Male; microbial communities; Microbiota; Middle Aged; Nutrition Assessment; oxidative phosphorylation; patients; quantitative polymerase chain reaction; remission; ribosomal RNA; RNA, Ribosomal, 16S - genetics

Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease in humans and is characterized by the presence of hyperactive immune cells and aberrant antibody responses to nuclear and cytoplasmic antigens, including characteristic anti–double-stranded DNA antibodies. We performe...