N-acetylaspartate/creatine and choline/creatine ratios in the thalami, insular cortex and white matter as markers of hypertension and cognitive impairment in the elderly

• Published in: Hypertension research Vol. 31; no. 10; pp. 1851 - 1857
• Main Authors: Ben Salem, Douraied, Walker, Paul M, Bejot, Yannick, Aho, Serge L, Tavernier, Béatrice, Rouaud, Olivier, Ricolfi, Frédéric, Brunotte, François
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.10.2008
• Subjects: Aged; Aged, 80 and over; Aging - metabolism; Aging - pathology; Aspartic Acid - analogs & derivatives; Aspartic Acid - metabolism; Biomarkers - metabolism; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Choline - metabolism; Cognition Disorders - metabolism; Cognition Disorders - pathology; Computer Science; Creatine - metabolism; Female; Humans; Hypertension - metabolism; Hypertension - pathology; Magnetic Resonance Imaging; Male; Medical Imaging; Middle Aged; Nerve Fibers, Myelinated - metabolism; Nerve Fibers, Myelinated - pathology; Neuropsychological Tests; Thalamus - metabolism; Thalamus - pathology; Trail Making Test; hypertension; proton magnetic resonance spectroscopy; elderly

Our objective was to investigate the influence of hypertension on N-acetylaspartate (NAA) and choline (Cho) ratios in brain tissues in a community-dwelling elderly population. Brain flexibility was also evaluated with regard to the same metabolite ratios. Proton magnetic resonance spectroscopy (MRS)...