Efficacy and Safety of Diclofenac–Hyaluronate Conjugate (Diclofenac Etalhyaluronate) for Knee Osteoarthritis: A Randomized Phase III Trial in Japan

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 73; no. 9; pp. 1646 - 1655
• Main Authors: Nishida, Yoshihiro, Kano, Kazuyuki, Nobuoka, Yuji, Seo, Takayuki
• Format: Journal Article
• Language: English
• Published: Atlanta Wiley Subscription Services, Inc 01.09.2021; John Wiley and Sons Inc
• Subjects: Adverse events; Anaphylaxis; Arthritis; Biomedical materials; Citric acid; Confidence intervals; Diclofenac; Evaluation; Full Length; Hyaluronic acid; Knee; Nonsteroidal anti-inflammatory drugs; Osteoarthritis; Pain; Placebos; Safety; Sodium citrate; Japan

Objective To confirm the efficacy and safety of intraarticular (IA) injection of diclofenac covalently linked to hyaluronic acid (diclofenac etalhyaluronate [DF‐HA]; ONO‐5704/SI‐613) in patients with knee osteoarthritis (OA). Methods In a phase III multicenter, randomized, double‐blind, placebo‐cont...