Differential binding efficiency between the envelope protein of Japanese encephalitis virus variants and heparan sulfate on the cell surface

• Published in: Journal of medical virology Vol. 72; no. 4; pp. 618 - 624
• Main Authors: Liu, Hsiuan, Chiou, Shyan-Song, Chen, Wei-June
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2004; Wiley-Liss
• Subjects: AE protein; Animals; Biological and medical sciences; Cell Line; Cell Membrane - virology; CHO Cells; Cricetinae; Encephalitis Virus, Japanese - genetics; Encephalitis Virus, Japanese - growth & development; Encephalitis Virus, Japanese - metabolism; envelope protein; Fundamental and applied biological sciences. Psychology; Genetic Variation; heparan sulfate; Heparitin Sulfate - biosynthesis; Heparitin Sulfate - genetics; Heparitin Sulfate - metabolism; Human viral diseases; Infectious diseases; Japanese encephalitis virus; JEV; Medical sciences; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Microbiology; Miscellaneous; Molecular Sequence Data; Mutation, Missense; Protein Binding; Receptors, Virus - physiology; Viral diseases; Viral Envelope Proteins - genetics; Viral Envelope Proteins - metabolism; Viral Plaque Assay; Virology; virus entry; virus variation; envelope protein; Flavivirus; Cell surface; Virus; Envelope virus; Binding protein; heparan sulfate; Efficiency; Japanese encephalitis virus; virus entry; JEV; Japanese encephalitis group virus; Flaviviridae; virus variation; Virus penetration

Japanese encephalitis (JE) virus infects a number of host cells, either mosquitoes or vertebrates, in nature. The viral envelope (E) protein is known to interact with molecule(s) on the cell membrane during the early stage of virus infection. In this study, two sets of virus variants including T1P1‐...